铜催化砜基诱导的区域选择性C(sp3)—H键杂芳基化反应
收稿日期: 2024-06-22
修回日期: 2024-07-09
网络出版日期: 2024-07-25
基金资助
国家自然科学基金(22001185); 江苏省高等学校基础科学(自然科学)研究重大项目(23KJA150007)
Cu-Catalyzed Regioselective Heteroarylation of C(sp³)—H Bond Induce by Sulfonyl Group
Received date: 2024-06-22
Revised date: 2024-07-09
Online published: 2024-07-25
Supported by
National Natural Science Foundation of China(22001185); Natural Science Foundation of the Jiangsu Higher Education Institutions of China(23KJA150007)
刘慧英 , 吴中天 , 李昊天 , 吴新鑫 . 铜催化砜基诱导的区域选择性C(sp3)—H键杂芳基化反应[J]. 有机化学, 2025 , 45(1) : 297 -306 . DOI: 10.6023/cjoc202406034
The regioselective carbon-hydrogen bond functionalization reaction in atom- and step-economy holds significant potential for the late-stage elaboration of complex molecules and natural products. In recent years, the hydrogen atom transfer strategy involving radicals has garnered considerable attention from chemists due to its high chemoselectivity and regioselectivity. However, owing to the marginal differences in bond dissociation energies (BDEs) among C(sp³)—H bonds, hydrogen atom transfer reactions mediated by alkyl radicals remain less-developed. A copper-catalyzed sulfone-induced regioselective C(sp³)—H bond heteroarylation reaction was reported. This strategy utilizes the α-alkyl radical of sulfone as an intramolecular hydrogen abstraction reagent, enabling the regioselective formation of carbon-nitrogen bonds under copper catalysis.
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