碳-碳不饱和键的催化不对称氢-膦(磷)官能化反应研究进展
收稿日期: 2024-05-30
修回日期: 2024-09-01
网络出版日期: 2024-09-10
基金资助
国家自然科学基金(22171029); 四川省自然科学基金(2024NSFSC0281)
Advances in Catalytic Asymmetric Hydrogen-Phosphine/Phosphorus Functionalization of Unsaturated Carbon-Carbon Bonds
Received date: 2024-05-30
Revised date: 2024-09-01
Online published: 2024-09-10
Supported by
National Natural Science Foundation of China(22171029); Natural Science Foundation of Sichuan Province(2024NSFSC0281)
手性含膦(磷)化合物广泛应用于医药、农业、材料以及不对称催化合成等领域, 因此, 发展高效方法用于合成结构多样的手性含膦(磷)化合物引起许多化学工作者的关注. 在已发展的众多合成策略中, 碳-碳不饱和键的催化不对称氢-膦(磷)官能化反应是一类高效且原子经济的方法. 利用该方法可以高效地合成多种类型的手性含膦(磷)化合物, 包括含有碳手性、轴手性、磷手性以及同时含有碳手性和磷手性中心的含膦(磷)化合物. 主要介绍了近十年碳-碳不饱和键的催化不对称氢-膦(磷)官能化反应的研究进展, 从反应机理、合成应用、存在的挑战以及未来的发展等方面进行了阐释与讨论.
关键词： 不对称催化; 碳-碳不饱和键; 氢-膦(磷)官能化; 手性含膦(磷)化合物; 膦(磷)试剂
孙婷珈 , 孙国银 , 孙威 , 彭雪松 , 廖娟 , 游勇 , 袁伟成 . 碳-碳不饱和键的催化不对称氢-膦(磷)官能化反应研究进展[J]. 有机化学, 2024 , 44(12) : 3647 -3677 . DOI: 10.6023/cjoc202405046
Phosphine/Phosphorus-containing chiral compounds have a wide range of applications in pharmaceuticals industry, agriculture, functionalized materials, and asymmetric catalysis. Accordingly, the development of efficient methods for the synthesis of structurally diverse phosphine/phosphorus-containing chiral compounds has attracted the attention of chemists. Among the multitude of synthetic strategies developed, catalytic asymmetric hydrogen-phosphine/phosphorus functiona- lization of unsaturated carbon-carbon bonds stands out as a particularly efficient and atom economical method. Utilizing this strategy, a wide array of phosphine/phosphorus-containing chiral compounds can be synthesized with remarkable efficiency. The state-of-the-art studies on catalytic asymmetric hydrogen-phosphine/phosphorus functionalization of unsaturated carbon- carbon bonds in past decade are summarized. Mechanistic insights, synthetic applications, as well as challenges and opportunities of this field are elucidated and discussed.
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