N-溴代丁二酰亚胺促进的P(O)-H化合物参与的醇的直接磷酸化反应
收稿日期: 2024-04-15
修回日期: 2024-05-08
网络出版日期: 2024-05-23
基金资助
贵州省中医药管理局课题(QZYY-2021-008); 国家自然科学基金(82360679); 贵州省基础研究(自然科学方向)(黔科合基础-ZK[2022]一般592)
N-Bromosuccinimide-Promoted Direct Phosphorylation of Alcohols with P(O)-H Compounds
Received date: 2024-04-15
Revised date: 2024-05-08
Online published: 2024-05-23
Supported by
Guizhou Provincial Administration of Traditional Chinese Medicine Project(QZYY-2021-008); National Natural Science Foundation of China(82360679); Guizhou Provincial Basic Research Program (Natural Science)(QKHJC-ZK[2022] General 592)
发展了一种温和、绿色、便捷和可扩大的N-溴代丁二酰亚胺(NBS)促进的次级膦氧化合物与醇的直接磷酸化策略, 用于合成多种次磷酸酯. 底物适用范围广泛且耐受性好, 能以中等至优异的收率(高达92%)合成目标化合物. 该反应在室温下进行, 无需添加任何氧化剂和金属催化剂, 为次磷酸酯衍生物的合成提供了一种新的策略.
关键词： 磷酸化; P—O键; 次磷酸酯; 醇; N-溴代丁二酰亚胺(NBS)
王华斌 , 徐连华 , 刘雄伟 , 潘博文 , 姚震 , 黄强 , 周英 . N-溴代丁二酰亚胺促进的P(O)-H化合物参与的醇的直接磷酸化反应[J]. 有机化学, 2024 , 44(9) : 2847 -2853 . DOI: 10.6023/cjoc20203002
A mild, green, convenient and scalable N-bromosuccinimide (NBS) promoted direct phosphorylation strategy of secondary phosphine oxides and alcohols for the synthesis of various phosphinate esters was developed. A variety of substrates are well-tolerated and the desirable compounds were afforded in moderate to excellent yields (up to 92%). This reaction is conducted at room temperature without the addition of any oxidant and metal catalyst, which provides a new strategy for the synthesis of phosphinate esters.
Key words： phosphorylation; P—O bond; phosphinate ester; alcohol; N-bromosuccinimide (NBS)
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