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2024 , Vol. 44 >Issue 12: 3621 - 3638

DOI: https://doi.org/10.6023/cjoc202406029

综述与进展

基于去对称化策略合成磷中心手性化合物的研究进展

  • 林国涛 ,
  • 许健 ,
  • 宋秋玲
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  • a 华侨大学材料科学与工程学院 福建厦门 361021
    b 福州大学化学学院 福州 350108

收稿日期: 2024-06-20

  修回日期: 2024-09-30

  网络出版日期: 2024-10-18

基金资助

国家自然科学基金(21602065); 国家自然科学基金(21931013); 福建省自然科学基金(2022J02009); 河南师范大学化学化工学院开放基金资助项目.

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Recent Advances in the Synthesis of P-Stereogenic Compounds via Desymmetrization Strategy

  • Guotao Lin ,
  • Jian Xu ,
  • Qiuling Song
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  • a College of Material Sciences & Engineering, Huaqiao University, Xiamen, Fujian 361021
    b College of Chemistry, Fuzhou University, Fuzhou 350108
*Corresponding authors. E-mail:;

Received date: 2024-06-20

  Revised date: 2024-09-30

  Online published: 2024-10-18

Supported by

National Natural Science Foundation of China(21602065); National Natural Science Foundation of China(21931013); Natural Science Foundation of Fujian Province(2022J02009); Open Research Fund of School of Chemistry and Chemical Engineering, Henan Normal University.

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摘要

有机磷化合物广泛存在于医药、材料、生命、合成等领域, 其中应用最为广泛的是手性磷化合物. 因此, 开展磷中心手性的构建研究一直是有机化学的研究热点和难点. 传统的合成方法主要是通过手性拆分及手性诱导实现. 近年来通过不对称催化实现磷中心的构建得到了迅速的发展. 本综述介绍了近十年来通过去对称化的策略来构建磷中心手性的研究进展, 主要是以官能团如C—H键、羟基、不饱和键的转化及其它一些类型的反应进行分类介绍, 并对该研究领域存在的一些问题和未来发展趋势进行了展望.

关键词： 磷中心手性; 去对称化; C—H键活化

本文引用格式

林国涛 , 许健 , 宋秋玲 . 基于去对称化策略合成磷中心手性化合物的研究进展[J]. 有机化学, 2024 , 44(12) : 3621 -3638 . DOI: 10.6023/cjoc202406029

Abstract

Organophosphorus compounds are extensively utilized in the field of medicine, materials, life sciences, and organic synthesis, among which chiral phosphorus compounds are the most widely used. Therefore, the construction of chiral phosphorus centers has always been the hotspot and challenge in organic synthesis. Traditional synthesis methods are mainly focused on chiral resolution and chiral induction strategies. Recently, the construction of chiral phosphorus centers via asymmetric catalysis has been well developed. The recently development of desymmetrization strategies in the construction of phos- phorus centers is summarized, mainly focused on the transformation of C—H, C=C, C≡C bonds and hydroxyl group. What’s more, the deficiencies of current strategies and the trends of future development have also been discussed.

Key words： P-stereogenic center; desymmetrization; C—H bond activation

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