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2025 , Vol. 45 >Issue 2: 516 - 530

DOI: https://doi.org/10.6023/cjoc202406033

综述与进展

过渡金属催化碳氢键活化合成烷基氟烷基化合物的研究进展

  • 王曼曼 ,
  • 习文慧 ,
  • 吴昊 ,
  • 白大昌
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  • 河南师范大学化学化工学院 抗病毒性传染病创新药物全国重点实验室 河南新乡 453007

收稿日期: 2024-06-22

  修回日期: 2024-08-23

  网络出版日期: 2024-10-18

基金资助

国家自然科学基金(22471063); 河南省自然科学基金(242300421351); 河南省自然科学基金(222102310562); 河南省博士后科研基金(202103087)

收起

Recent Advances in Transition-Metal Catalyzed C—H Bond Activation for the Synthesis of C(sp3)-Fluoroalkyl Compounds

  • Manman Wang ,
  • Wenhui Xi ,
  • Hao Wu ,
  • Dachang Bai
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  • State Key Laboratory of Antiviral Drugs, School of Chemistry and Chemical Engineering, Henan Normal University, Xinxiang, Henan 453007
*E-mail:

Received date: 2024-06-22

  Revised date: 2024-08-23

  Online published: 2024-10-18

Supported by

National Natural Science Foundation of China(22471063); Natural Science Foundation of Henan Province(242300421351); Natural Science Foundation of Henan Province(222102310562); Henan Provincial Postdoctoral Science Foundation(202103087)

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摘要

过渡金属催化碳氢键活化是人们研究的热点领域之一. 通过碳氢键断裂合成有机氟化合物是一种直接、高效的合成方法. 相对于芳基/炔基取代氟烷基化合物的合成, 过渡金属催化烷基氟烷基化合物(C(sp3)-Rf)的合成相对比较滞后. 此文主要介绍了近些年过渡金属(铑、钌、钯、铜、铱、镍和锰等)催化碳氢键(sp2或sp3 C—H键)活化合成烷基氟烷基化合物的研究进展, 最后总结了近期出现的几例利用碳氢键活化合成手性含氟化合物的方法.

关键词： 碳氢键活化; 过渡金属催化; 烷基氟烷基化合物

本文引用格式

王曼曼 , 习文慧 , 吴昊 , 白大昌 . 过渡金属催化碳氢键活化合成烷基氟烷基化合物的研究进展[J]. 有机化学, 2025 , 45(2) : 516 -530 . DOI: 10.6023/cjoc202406033

Abstract

Transition-metal catalyzed insert C—H bond activation has gained great attention for the last decades, which would provide a straightforward and attractive strategy for the synthesis of organofluorine compounds. Compared with aryl and alkynyl fluoroalkyl compounds, the synthesis of C(sp3)-fluoroalkyl compounds through C—H bond activation still lag behind. This review highlights the recent advances in the synthesis of alkyl fluoroalkyl compounds through the transition-metal (Rh, Ru, Pd, Cu, Ir, Ni, Mn, etc.) catalyzed C—H bond activation. The very recently developed chiral fluorinated compound synthesis through asymmetric C—H bond activation is included.

Key words： C—H bond activation; transition-metal catalyst; C(sp3)-fluoroalkyl compounds

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