多卤代海洋来源天然产物全合成
收稿日期: 2024-08-30
修回日期: 2024-10-01
网络出版日期: 2024-11-20
基金资助
国家自然科学优秀青年基金(82122063)
Total Syntheses of Marine-Derived Polyhalogenated Natural Products
Received date: 2024-08-30
Revised date: 2024-10-01
Online published: 2024-11-20
Supported by
National Natural Science Foundation of China for Excellent Young Scholars(82122063)
卤素掺入是海洋生物用于修饰其多用途代谢物的一种独特策略, 通常会导致生物活性以及体内代谢或降解历程的改变. 同时, 卤素的引入也会增加海洋天然产物结构的复杂性及其鉴定难度. 近年来多卤取代的海洋来源天然产物独特的化学结构与多样性的生物学功能引起了有机合成化学家的广泛兴趣. 此综述将从多卤吲哚生物碱(Caulamidines, Perophoramidine, Hinckdentine A, Spiroindimicins, Dictazole B, Securiflustra securifrons, Nortopsentin D)、其它多卤生物碱(Psammaplysins, Massadine, Axinellamine, Discorhabdins)和典型多卤甾体天然产物(Clionastatins)三个方面总结近年来多卤取代的海洋来源天然产物全合成的研究进展.
杨庆星 , 刘璇 , 马硕 , 李欣欣 , 马东旭 , 徐涛 . 多卤代海洋来源天然产物全合成[J]. 有机化学, 2025 , 45(3) : 764 -803 . DOI: 10.6023/cjoc202408037
The incorporation of halogens is a unique strategy employed by marine organisms to modify their multifunctional metabolites, often leading to changes in biological activity and the metabolic or degradation processes in vivo. At the same time, the introduction of halogens increases the structural complexity of marine natural products, making their identification more challenging. In recent years, the unique chemical structures and diverse biological functions of polyhalogenated marine-derived natural products have garnered significant interest from organic synthetic chemists. Recent advances in the total synthesis of polyhalogenated marine-derived natural products, focusing on polyhalogenated indole alkaloids (Caulamidines, Perophoramidine, Hinckdentine A, Spiroindimicins, Dictazole B, Securiflustra securifrons, Nortopsentin D), other polyhalogenated alkaloids (Psammaplysins, Massadine, Axinellamine, Discorhabdins), and representative polyhalogenated steroidal natural products (Clionastatins) are summarized.
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