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2025 , Vol. 45 >Issue 4: 1276 - 1282

DOI: https://doi.org/10.6023/cjoc202411014

研究论文

碘化亚铜/4-羟基吡啶酰肼催化的(杂)芳基氯代物和苯基亚磺酸钠的偶联反应

  • 李赛洛 ,
  • 马大为
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  • a 上海科技大学物质学院 上海 201210
    b 中国科学院上海有机化学研究所 生命过程小分子调控全国重点实验室 上海 200032

收稿日期: 2024-11-14

  修回日期: 2024-11-26

  网络出版日期: 2024-11-28

基金资助

国家自然科学基金(21991110)

收起

CuI/4-Hydroxy Picolinohydrazide Catalyzed Coupling Reaction of (Hetero)aryl Chlorides with Sodium Aryl Sulfinates

  • Sailuo Li ,
  • Dawei Ma
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  • a School of Physical Science and Technology, ShanghaiTech University, Shanghai 201210
    b State Key Laboratory of Bioorganic and Natural Products Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai 200032
* E-mail:

Received date: 2024-11-14

  Revised date: 2024-11-26

  Online published: 2024-11-28

Supported by

National Natural Science Foundation of China(21991110)

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摘要

采用一种新型的4-羟基吡啶甲酰胺配体, 成功地完成了之前难以反应的芳基氯化物和苯基亚磺酸钠的铜催化偶联, 这代表着这两类底物的第一次金属催化的偶联反应. 反应在130 ℃下进行, 生成二芳基砜, 收率在53%~96%. 底物可以兼容各种电性的芳基氯和杂芳基氯.

关键词： 偶联反应; 铜催化; 配体; 芳基氯代物; 二芳基砜

本文引用格式

李赛洛 , 马大为 . 碘化亚铜/4-羟基吡啶酰肼催化的(杂)芳基氯代物和苯基亚磺酸钠的偶联反应[J]. 有机化学, 2025 , 45(4) : 1276 -1282 . DOI: 10.6023/cjoc202411014

Abstract

By using a newly developed 4-hydroxy picolinohydrazide as the ligand, Cu-catalyzed coupling of (hetero)aryl chlorides with sodium aryl sulfonates proceeded smoothly at 130 ℃ to give a series of biarylsulfones in 53%~96% yields. This represents the first metal-catalyzed coupling reaction of (hetero)aryl chlorides with sodium aryl sulfonates. Aryl and heteroaryl chlorides bearing either electron-donating or electron-withdrawing groups were applicable for this coupling reaction.

Key words： coupling reaction; copper catalysis; ligand; (hetero)aryl chloride; biarylsulfone

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