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2025 , Vol. 45 >Issue 3: 945 - 950

DOI: https://doi.org/10.6023/cjoc202409041

研究论文

赛克洛霉素还原端Fuc-Agl片段的合成

  • 符登宪 ,
  • 许恃维 ,
  • 孟令奎 ,
  • 万谦 ,
  • 曾静
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  • a 华中科技大学同济医学院药学院 湖北省天然药物化学与资源评价重点实验室 武汉 430030
    b 武汉大学药学院 武汉 430071

收稿日期: 2024-09-28

  修回日期: 2024-11-14

  网络出版日期: 2024-12-20

基金资助

国家自然科学基金(22277033); 国家自然科学基金(22077039); 国家自然科学基金(22025102); 国家自然科学基金(22177034)

收起

Synthesis of the Reducing End Fuc-Agl Fragment of Saccharomicins

  • Dengxian Fu ,
  • Shiwei Xu ,
  • Lingkui Meng ,
  • Qian Wan ,
  • Jing Zeng
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  • a Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation, School of Pharmacy, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030
    b School of Pharmaceutical Sciences, Wuhan University, Wuhan 430071
* E-mail: ;
;

Received date: 2024-09-28

  Revised date: 2024-11-14

  Online published: 2024-12-20

Supported by

National Natural Science Foundation of China(22277033); National Natural Science Foundation of China(22077039); National Natural Science Foundation of China(22025102); National Natural Science Foundation of China(22177034)

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摘要

报道了赛克洛霉素A和B中还原端Fuc-Agl片段的合成. 该合成工作包含了牛磺酸的组装、β-糖苷键的构建、硫酸酯基团的引入以及最终的全去保护等关键的步骤. 最终通过8步线性步骤以42.4%的总收率获得了具备磺酸和硫酸官能团的Fuc-Agl片段.

关键词： 赛克洛霉素; Fuc-Agl片段; 化学合成; 硫酸化

本文引用格式

符登宪 , 许恃维 , 孟令奎 , 万谦 , 曾静 . 赛克洛霉素还原端Fuc-Agl片段的合成[J]. 有机化学, 2025 , 45(3) : 945 -950 . DOI: 10.6023/cjoc202409041

Abstract

The Fuc-Agl fragment situated at the reducing terminus of saccharomicins A and B was effectively synthesized. The synthesis encompassed pivotal procedures including taurine assembly, β-glycosidic bond establishment, sulfate ester incorporation, and ultimate deprotection, all of which were executed proficiently, culminating in an aggregate yield of 42.4% across 8 sequential steps.

Key words： saccharomicins; Fuc-Agl fragment; chemical synthesis; sulfation

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