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DOI: https://doi.org/10.6023/cjoc202507026

研究论文

铟促进的硒代芳基-2,2-二甲基丁硒酸酯的高效合成

  • Yang ,
  • Kai ,
  • Shan ,
  • Shen ,
  • Chen ,
  • Weiming ,
  • Huang ,
  • Jiuzhong ,
  • Zhang ,
  • Yi ,
  • Wu ,
  • Qingrong ,
  • Wu ,
  • Gaorong
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  • a赣南医科大学药学院, 江西省中药药理重点实验室 赣州 341000
    b赣州市第五人民医院药剂科,赣州肝病研究所 赣州 341000
†共同第一作者

收稿日期: 2025-07-19

  修回日期: 2025-09-23

  网络出版日期: 2025-10-30

基金资助

江西省职业早期青年科技人才培养专项项目(No. 20244BCE52224),江西省自然科学基金(No. 20252BAC200240)资助项目.

收起

Indium-Promoted Efficient Synthesis of Se-Aryl- 2,2-Dimethylbutaneselenoates

  • 杨凯 ,
  • 单申 ,
  • 陈伟铭 ,
  • 黄九忠 ,
  • 张毅 ,
  • 吴庆荣 ,
  • 吴高荣
Expand
  • aJiangxi Province Key Laboratory of Pharmacology of Traditional Chinese Medicine, School of Pharmacy, Gannan Medical University, Ganzhou, 341000
    bDepartment of Pharmacy, Ganzhou Liver Institute, Ganzhou Fifth People's Hospital, Ganzhou 341000

Received date: 2025-07-19

  Revised date: 2025-09-23

  Online published: 2025-10-30

Supported by

Early-Career Young Scientists and Technologists Project of Jiangxi Province (No. 20244BCE52224), Jiangxi Provincial Natural Science Foundation (No. 20252BAC200240).

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摘要

硒酯类化合物具有重要的生物活性功能,广泛用于天然产物、蛋白质中间体、超导材料的合成中。然而,目前硒酯的构建方法存在催化剂昂贵、反应步骤多、产率低、对大位阻酰氯效率差等缺陷。本文报道了一种铟促进的硒代芳基-2,2-二甲基丁硒酸酯的高效合成方法。该方该底物适用范围广、反应条件温和、操作简便,能以中等至优异的产率获得目标产物。此外,该方法可顺利进行克级放大,为该类结构的后续衍生化奠定基础。

关键词： 有机硒化物; 铟促进; 硒代芳基-2,2-二甲基丁硒酸酯

本文引用格式

Yang , Kai , Shan , Shen , Chen , Weiming , Huang , Jiuzhong , Zhang , Yi , Wu , Qingrong , Wu , Gaorong . 铟促进的硒代芳基-2,2-二甲基丁硒酸酯的高效合成[J]. 有机化学, 0 : 0 . DOI: 10.6023/cjoc202507026

Abstract

Selenoester compounds exhibit significant biological activity and are widely used in the synthesis of natural products, protein intermediates, and superconducting materials. However, current methods for constructing selenoesters suffer from drawbacks such as expensive catalysts, multiple reaction steps, low yields, and poor efficiency to sterically hindered acyl chlorides. Here, an efficient indium-promoted method for the synthesis of Se-aryl-2,2-dimethylbutaneselenoates is developed. The strategy features broad substrate scope, mild reaction conditions and simple operation, offering the desired products in moderate to excellent yields. Furthermore, the gram-scale reaction can be conducted smoothly, laying the foundation for subsequent derivatization of such structures.

Key words： organoselenium compounds; indium-promoted; Se-aryl-2,2-dimethylbutaneselenoates

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