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DOI: https://doi.org/10.6023/cjoc202507023

研究论文

铑催化由环丙烯酮合成酰偶姻衍生物

  • 任才艺 ,
  • 董文楠 ,
  • 刘敬功 ,
  • 杨爽 ,
  • 房新强
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  • a福州大学化学化工学院 福州 350116
    b中国科学院福建物质结构研究所 福州 350100
    c广州中医药大学第二附属医院 广州 510120

收稿日期: 2025-07-16

  修回日期: 2025-09-24

  网络出版日期: 2025-11-05

基金资助

国家自然科学基金资助项目

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Rhodium-catalyzed synthesis of acyloin derivatives from cyclopropenones

  • Caiyi Ren ,
  • Wennan Dong ,
  • Jinggong Liu ,
  • Shuang Yang ,
  • Xinqiang Fang
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  • aCollege of Chemistry, Fuzhou University, Fuzhou, 350116
    bFujian Institute of Research on the Structure of Matter, Fuzhou, 350100
    cThe Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, 350120

Received date: 2025-07-16

  Revised date: 2025-09-24

  Online published: 2025-11-05

Supported by

NSFC (No. 22071242 and 21871260).

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摘要

环丙烯酮已被广泛应用于催化条件下的开环或扩环反应,用于制备不饱和羰基化合物. 本工作中,我们首次实现了铑催化的芳基/烷基取代环丙烯酮的开环反应,成功合成了酰偶姻衍生物。该反应代表了环丙烯酮参与的一种新型反应模式。所得酰偶姻产物是一类重要的有机合成砌块,同时也是众多天然产物的骨架结构.

关键词： 环丙烯酮; 铑催化; 酰偶姻; 开环反应

本文引用格式

任才艺 , 董文楠 , 刘敬功 , 杨爽 , 房新强 . 铑催化由环丙烯酮合成酰偶姻衍生物[J]. 有机化学, 0 : 0 . DOI: 10.6023/cjoc202507023

Abstract

Cyclopropenones have been extensively utilized in catalytic ring-opening and ring-expansion reactions for the synthesis of unsaturated carbonyl compounds. In this study, we have accomplished the first rhodium-catalyzed ring-opening reaction of aryl-/alkyl-substituted cyclopropenones, successfully affording acyloin derivatives. This transformation represents a novel reaction pattern involving cyclopropenones. The resulting acyloin products constitute important building blocks in organic synthesis and serve as fundamental structural frameworks in numerous natural products.

Key words： cyclopropenone; rhodium catalysis; acyloin; ring-opening reaction

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