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DOI: https://doi.org/10.6023/cjoc202508025

研究论文

仿生四齿胺基吡啶锰催化剂/H2O2的醇类化合物高效氧化：间歇和连续流研究

  • Xia Chunnian ,
  • Chen Kailin ,
  • Jin ,
  • Nuoqi ,
  • Nan Xinghui ,
  • Wang Bingyang ,
  • Wu Xinyi ,
  • Sun Qiangsheng ,
  • Sun Wei
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  • a浙江工业大学药学院 杭州 310014;
    b中国科学院兰州化学物理研究所 低碳催化与二氧化碳利用国家重点实验室 兰州 730000

收稿日期: 2025-08-28

  修回日期: 2025-11-01

  网络出版日期: 2025-12-10

基金资助

国家自然科学基金(No. 22361142751, 22372183, 22302213)、甘肃省重大科技专项(No. 22ZD6GA003)、中国科学院兰州化学物理研究所重点培育项目(No. ZYFZFX-9)

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Efficient Oxidation of Alcohols Using a Bioinspired Tetradentate Aminopyridine Manganese Catalyst with H2O2: Batch and Continuous Flow Studies

  • 夏春年 ,
  • 陈凯林 ,
  • 金诺琪 ,
  • 南欣卉 ,
  • 汪兵洋 ,
  • 吴馨怡 ,
  • 孙强盛 ,
  • 孙伟
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  • aCollege of Pharmaceutical Sciences, Zhejiang University of Technology, Hangzhou 310014;
    bState Key Laboratory for Low Carbon Catalysis and CO2 Utilization, Lanzhou Institute of Chemical Physics, Lanzhou 730000

Received date: 2025-08-28

  Revised date: 2025-11-01

  Online published: 2025-12-10

Supported by

National Natural Science Foundation of China (No. 22361142751, 22372183, 22302213), the Major Project of Gansu Province, China (No. 22ZD6GA003), and the Major Program of the Lanzhou Institute of Chemical Physics, CAS (No. ZYFZFX-9).

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摘要

仿生四齿胺基吡啶锰配合物（Mn-N4）已在各种选择性氧化反应中展示出优异的催化活性。本文我们报道了一系列 Mn-N4 的合成及其在催化仲醇氧化中的应用。该方法利用过氧化氢(H2O2)作为环境友好的氧化剂,并加入少量乙酸作为添加剂。值得注意的是,该催化剂体系的连续流工艺实现了快速转化,将反应时间从传统间歇体系的90分钟缩短到连续流工艺中的停留时间1.6分钟。这种方法为仲醇的工业氧化提供了一种有前途且实用的策略,显示出更广泛的应用潜力。

关键词： 仿生催化; 醇的氧化; 锰配合物; 连续流

本文引用格式

Xia Chunnian , Chen Kailin , Jin , Nuoqi , Nan Xinghui , Wang Bingyang , Wu Xinyi , Sun Qiangsheng , Sun Wei . 仿生四齿胺基吡啶锰催化剂/H2O2的醇类化合物高效氧化：间歇和连续流研究[J]. 有机化学, 0 : 8025 . DOI: 10.6023/cjoc202508025

Abstract

Bioinspired manganese complexes with tetradentate aminopyridine ligands (N4) have shown excellent promise as effective catalysts for various selective oxidation reactions. In this study, we report the synthesis of a series of Mn-N4 and their application in the catalytic oxidation of secondary alcohols. This method utilizes hydrogen peroxide as an environmentally benign oxidant, with a small amount of acetic acid as an additive. Notably, the continuous-flow process using this catalyst system achieves rapid conversion, reducing the reaction time from 90 min in a traditional batch system to 1.6 min residence time in the continuous-flow process. This approach offers a promising and practical strategy for the industrial oxidation of secondary alcohols, demonstrating significant potential for broader applications.

Key words： bioinspired catalysis; oxidation of alcohols; manganese complexes; continuous flow

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