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DOI: https://doi.org/10.6023/cjoc202601025

综述与进展

利巴韦林的结构修饰及应用研究进展

  • 吕洁 ,
  • 李停停
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  • 1重庆第二师范学院生物与化学工程学院 重庆 400067;
    2贵州大学绿色农药全国重点实验室 贵阳 550025

收稿日期: 2026-01-19

  修回日期: 2026-03-01

  网络出版日期: 2026-05-07

基金资助

重庆市教委科学技术研究计划项目(No. KJQN202501618)及重庆第二师范学院项目(No. BSRC2024070, No. 2025XJQNXZTJ05)资助项目.

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Recent Advances in the Structural Modifications and Applications of Ribavirin

  • Lv Jie ,
  • Li Tingting
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  • 1Department of Biological and Chemical Engineering, Chongqing University of Education, Chongqing 400067, China;
    2State Key Laboratory of Green Pesticide, Guizhou University, Guiyang 550025, China

Received date: 2026-01-19

  Revised date: 2026-03-01

  Online published: 2026-05-07

Supported by

Science and Technology Research Program of Chongqing Municipal Education Commission (No. KJQN202501618), and the University-level Project of Chongqing University of Education (No. BSRC2024070, No. 2025XJQNXZTJ05).

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摘要

对核苷类似物进行结构修饰是研发新型药物的重要策略。利巴韦林作为代表性核苷类似物之一,是一种广谱抗病毒药物。然而,长期或过量使用可能导致白细胞减少、抑制红细胞生成等副作用。因此,大量研究致力于开发高效低毒的利巴韦林衍生物。本文系统总结了利巴韦林的结构修饰及应用,主要包括：1)糖基修饰;2)碱基修饰。同时,也探讨了新的合成方法及其在药物开发中的潜在应用,以期为新型抗病毒药物的研发提供参考。

关键词： 利巴韦林; 结构修饰; 应用; 糖基修饰; 碱基修饰

本文引用格式

吕洁 , 李停停 . 利巴韦林的结构修饰及应用研究进展[J]. 有机化学, 0 : 202601025 . DOI: 10.6023/cjoc202601025

Abstract

Structural modification of nucleoside analogues is an important strategy for developing novel drugs. Ribavirin, as one of the representative nucleoside analogues, is a broad-spectrum antiviral nucleoside drug. However, its prolonged or excessive use can lead to side effects, such as reduction in white blood cell count and inhibition of red blood cell production. Therefore, extensive research has focused on developing ribavirin derivatives with improved efficacy and reduced toxicity. This minireview systematically summarizes the structural modifications and applications of ribavirin, primarily including: 1) glycosyl modifications and 2) base modifications. Additionally, novel synthetic methods and potential applications in drug development are discussed, providing insights for the development of novel antiviral drugs.

Key words： Ribavirin; Structural Modification; Application; Glycosyl Modification; Base Modification

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