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0 202604019

DOI: https://doi.org/10.6023/cjoc202604019

研究论文

可见光驱动CF3Br与未活化烯烃的溴-三氟甲基化反应研究

  • 赵明琪 ,
  • 黄丹凤 ,
  • 温欢 ,
  • 张丹 ,
  • 王克虎 ,
  • 王君姣 ,
  • 张博生 ,
  • 胡雨来
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  • 西北师范大学化学化工学院 兰州 730070

收稿日期: 2026-04-12

  修回日期: 2026-06-04

  网络出版日期: 2026-08-17

基金资助

国家自然科学基金(Nos. 22461038)资助项目.

收起

Visible-Light Promoted Bromotrifluoromethylation Reaction of CF3Br with Unactivated Alkenes

  • Zhao Mingqi ,
  • Huang Danfeng ,
  • Wen Huan ,
  • Zhang Dan ,
  • Wang Ke-Hu ,
  • Wang Junjiao ,
  • Zhang Bo-Sheng ,
  • Hu Yulai
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  • College of Chemistry and Chemical Engineering, Northwest Normal University, Lanzhou 730070

Received date: 2026-04-12

  Revised date: 2026-06-04

  Online published: 2026-08-17

Supported by

National Natural Science Foundation of China (Nos. 22461038).

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摘要

以fac-IrIII(ppy)3为光催化剂,实现了可见光驱动CF3Br与未活化烯烃的溴-三氟甲基化反应．在反应中,CF3Br作为双功能试剂,可同时提供三氟甲基源与溴源．该方法具有区域选择性高、反应条件温和、原子利用率高、产率良好等特点,为构建结构多样的β-三氟甲基溴代烃,提供了一种经济实用的新方法．

关键词： 可见光; CF3Br; 未活化烯烃; 溴-三氟甲基化; 双功能三氟甲基试剂

本文引用格式

赵明琪 , 黄丹凤 , 温欢 , 张丹 , 王克虎 , 王君姣 , 张博生 , 胡雨来 . 可见光驱动CF3Br与未活化烯烃的溴-三氟甲基化反应研究[J]. 有机化学, 0 : 202604019 . DOI: 10.6023/cjoc202604019

Abstract

A visible-light promoted bromotrifluoromethylation reaction of CF3Br with unactivated alkenes was achieved in the presence of catalytic amount of fac-IrIII(ppy)3. In the reaction, CF3Br serves as a bifunctional reagent to provide both the CF3 group and bromine source. The method features high regioselectivity, mild reaction conditions, high atom economy and good yields, which offers an economical and practical method for the construction of structurally diverse β-trifluoromethylated alkyl bromides.

Key words： visible-light catalysis; CF3Br; unactivated alkenes; bromotrifluoromethylation; bifunctional trifluoromethylating reagents

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