本文报道了锆路易斯酸催化的de Mayo型扩环反应。反应仅使用低价易得的氯化锆作为催化剂,无需使用任何外部光敏剂和添加剂。反应通过环状β-二羰基化合物与烯烃之间的自由基环加成和逆羟醛串联过程进行,不仅可在室温条件下高效进行,且具有良好的底物适用性。该策略旨在通过易得的起始原料,合成一系列官能团化的中环骨架。
王钧锋
,
刘芮碹
,
米学玲
,
罗三中
. 锆路易斯酸催化的环状β-二羰基化合物的de Mayo型扩环反应[J]. 有机化学, 0
: 202607015
.
DOI: 10.6023/cjoc202607015
Zirconium-Lewis acid was developed to facilitate a de Mayo-type ring expansion reaction in the absence of external photosensitizers and additives. The reaction proceeds through a [2+2] cycloaddition and retro-Aldol sequence between cyclic β-ketocarbonyls and alkenes, which are compatible with various substrates in good yields. Through this strategy, a series of functionalized medium sized-ring skeletons can be constructed starting from readily available starting materials.
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