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DOI: https://doi.org/10.6023/cjoc202608018

研究论文

雕白粉作为一碳合成子的[3+1+1]环化合成1,4,5-三取代咪唑

  • 朱法川 ,
  • 刘云云 ,
  • 万常峰 ,
  • 张闻博 ,
  • 万结平
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  • a江西师范大学化学与材料学院 南昌 330022;
    b南京林业大学林产化学与材料国际创新高地 南京 210037;
    c长沙医学院功能核酸基础与临床湖南省普通高校重点实验室 长沙 410219

收稿日期: 2026-08-18

  修回日期: 2026-09-03

  网络出版日期: 2026-09-16

基金资助

国家自然科学基金(No. 22561026)和江西省自然科学基金(20262BAC250114)资助项目.

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Rongalite as C1 synthon for 1,4,5-Trisubstituted Imidazole Synthesis via [3+1+1] Cyclization

  • Fachuan Zhu ,
  • Yunyun Liu ,
  • Chengfeng Wan ,
  • Wen-Bo Zhang ,
  • Jieping Wan
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  • aCollege of Chemistry and Materials, Jiangxi Normal University, Nanchang, 330022;
    bInternational Innovation Center for Forest Chemicals and Materials, Nanjing Forestry University, Nanjing, 210037;
    cHunan Provincial University Key Laboratory of the Fundamental and Clinical Research on Functional Nucleic Acid, Changsha Medical University, Changsha, 410219

Received date: 2026-08-18

  Revised date: 2026-09-03

  Online published: 2026-09-16

Supported by

National Natural Science Foundation of China (No. 22561026) and Jiangxi Provincial Natural Science Foundation (20262BAC250114).

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摘要

本文报道一例绿色高效的三组分环化方法用于咪唑合成. 采用廉价雕白粉作为一碳合成子和吖丙啶以及胺反应, 在乙醇绿色溶剂中合成系列1,4,5-三取代咪唑. 该工作是首次采用雕白粉为一碳合成子合成咪唑. 和传统采用醛作为一碳合成子的方法相比, 该工作使用雕白粉展示了对不同底物更大的兼容性, 以非常广泛的适用性合成了咪唑产物.

关键词： 环化; 雕白粉; 咪唑; 芳基化

本文引用格式

朱法川 , 刘云云 , 万常峰 , 张闻博 , 万结平 . 雕白粉作为一碳合成子的[3+1+1]环化合成1,4,5-三取代咪唑[J]. 有机化学, 0 : 202608018 -202608018 . DOI: 10.6023/cjoc202608018

Abstract

Reported herein is an efficient and green one-pot, three-component cyclization tactic for imidazole synthesis. With cheap rongalite as C1 synthon to react with 2H-azirines and amines, a series of 1,4,5-trisubstituted imidazoles have been synthesized in green EtOH medium. The work represents the first example on imidazole synthesis with rongalite as C1 synthon. Comparing with traditional method using aldehyde C1 synthon, rongalite displays evidently expanded tolerance to different types of substrates in the current work, enabling the synthesis of imidazole with rather broad scope.

Key words： cyclization; rongalite; imidazole; arylation

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