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0 202604004

DOI: https://doi.org/10.6023/cjoc202604004

综述与进展

碳磷键（C-P）的构建方法及研究进展

  • Xu ,
  • Ying ,
  • Wei ,
  • Yangyang ,
  • Cui ,
  • Dapeng ,
  • Dong ,
  • Zhiqiang ,
  • Zhu ,
  • Houhong ,
  • Yu ,
  • Miao ,
  • Song ,
  • Dongxue ,
  • Wang ,
  • Jiaru ,
  • Liu ,
  • Yukai ,
  • Sun ,
  • Kai ,
  • Liu ,
  • Yingjie
展开
  • a哈尔滨商业大学药物工程技术研究中心 哈尔滨 150076;
    b南京林业大学国际林化与材料创新中心, 中国南京 210037

收稿日期: 2026-06-24

  修回日期: 2026-08-09

  网络出版日期: 2026-09-22

基金资助

黑龙江省自然联合引导培育项目（No.PL2024H198）; 黑龙江省省属本科高校优秀青年教师基础研究支持计划（No. YQJH2024096）; 黑龙江省中医药科研项目（No.ZHY2026-50）.

收起

Research Progress in the Construction Methods of Carbon-Phosphorus (C-P) Bonds

  • 许颖 ,
  • 魏洋洋 ,
  • 崔大鹏 ,
  • 董志强 ,
  • 朱厚宏 ,
  • 于淼 ,
  • 宋冬雪 ,
  • 王加茹 ,
  • 刘玉凯 ,
  • 孙凯 ,
  • 刘颖杰
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  • aEngineering Research Center for Medicine, Harbin University of Commerce, Harbin, 150076;
    bInternational Innovation Cen ter for Forest Chemicals and Materials, Nanjing Forestry University, Nanjing 210037, China

Received date: 2026-06-24

  Revised date: 2026-08-09

  Online published: 2026-09-22

Supported by

Heilongjiang Province Natural Joint Guidance Cultivation Project(No. PL2024H198).Project supported by Basic Research Support Program for Outstanding Young Teachers in Provincial Undergraduate Colleges and Universities in Heilongjiang Province (No. YQJH2024096).Heilongjiang Province Scientific Research Project on Traditional Chinese Medicine (No.No.ZHY2026-50).

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摘要

碳磷键（C-P）是连接有机骨架和含磷基团的核心化学键,在合成药物、农药与功能材料的研究中,碳磷键的构建是至关重要的。近年来,随着过渡金属催化、光催化的迅速发展,构建碳磷键的课题也一直被科学家格外关注,研究成果层出不穷。在这样的背景下,本文从过渡金属催化、光催化以及其他方法催化等方面,归纳总结近年来,尤其是2023至2026年碳磷键构建的代表性进展,并对其反应机理进行详细阐述。

关键词： C-P键构建; 过渡金属催化; 光催化

本文引用格式

Xu , Ying , Wei , Yangyang , Cui , Dapeng , Dong , Zhiqiang , Zhu , Houhong , Yu , Miao , Song , Dongxue , Wang , Jiaru , Liu , Yukai , Sun , Kai , Liu , Yingjie . 碳磷键（C-P）的构建方法及研究进展[J]. 有机化学, 0 : 202604004 . DOI: 10.6023/cjoc202604004

Abstract

The carbon-phosphorus (C-P) bond is a key chemical linkage connecting organic frameworks with phosphorus-containing groups and plays a vital role in the synthesis of pharmaceuticals, pesticides, and functional materials. In recent years, with the rapid development of transition-metal catalysis and photocatalysis, the construction of C-P bonds has attracted considerable attention from scientists, leading to a continuous emergence of significant research achievements. In this context, this paper summarizes the representative advances in C-P bond construction in recent years, particularly from 2023 to 2026, from the perspectives of transition-metal catalysis, photocatalysis, and other catalytic methods, and provides a detailed discussion of the corresponding reaction mechanisms.

Key words： C-P Bond Construction; Transition metal catalysis; Photocatalysis

参考文献

[1] Saad H.; Elfeky S. A.; El-Gamel, N. E. A.; Abo Dena, A. S.RSC Advances. 2025, 15, 40802-40822.
[2] Demkowicz S.; Rachon J.; Daśko M.; Kozak W.RSC Advances. 2016, 6, 7101-7112.
[3] 任飞; 刘禹辰; 刘佳; 张虔榕; 孙督翁; 曹硕; 颜旗池; 李立衡; 何宾宾. Eco-Industry Science & Phosphorus Fluorine Engineering. 2026, 41, 6.
[4] Kolodiazhnyi O. I.Symmetry. 2021, 13, 889.
[5] Finkbeiner P.; Hehn J. P.; Gnamm C.Journal of Medicinal Chemistry. 2020, 63, 7081-7107.
[6] 朱家辉; 赵亮; 李扬; 束文圣; 李春连. Ecological Science. 2025, 44
[7] Kim D. H.; Lees W. J.Biochemistry. 2025, 64, 1720-1727.
[8] Tachallait H.;Pires Goncalves, L. C.; Benhida, R.Eur J Med Chem. 2026, 302, 118236.
[9] Barbosa J. S.;Almeida Paz, F. A.; Braga, S. S.Journal of Medicinal Chemistry. 2021, 64, 1260-1282.
[10] Duke S. O.; Powles S. B.Pest Manag Sci. 2008, 64, 319-325.
[11] Brahmachari G.Green synthetic approaches in organophosphorus chemistry: recent developments. In Organophosphorus Chemistry: Volume 50, Higham, L. J., Allen, D. W., Tebby, J. C. Eds.; Vol. 50; The Royal Society of Chemistry, 2021; p 0.
[12] Banerjee I.; Panda T. K.Organic & Biomolecular Chemistry. 2021, 19, 6571-6587.
[13] Wauters I.; Debrouwer W.; Stevens C. V.Beilstein Journal of Organic Chemistry. 2014, 10, 1064-1096.
[14] Gan L.; Ye C.; Pi T.; Wang L.; Li C.; Liu L.; Huang T.; Chen T.; Han L.-B.The Journal of Organic Chemistry. 2024, 89, 7047-7057.
[15] Kumaresh K. G.; Manikpuri D.; Gunanathan C.Org Lett. 2025, 27, 10570-10575.
[16] Li J. X.; Tian R.; Zhu Y. M.J Org Chem. 2025, 90, 3184-3193.
[17] Wu Y.; Tang Z.; Li X.; Lv X.; Chai J.; Zhao F.; Wu J.Org Lett. 2025, 27, 6031-6036.
[18] Keshari P.; Yadav R.; Mata P.; Hazra S.ACS Sustainable Chemistry & Engineering. 2024, 12, 11473-11479.
[19] Xu B.; Gao Z.; Liu C.; Zhang J.; Li J.; Li X.; Hu T.ACS Catalysis. 2025, 15, 18623-18630.
[20] Dan J. H.; Huang R.; Wang J.; Cheng C. R.J Org Chem. 2024, 89, 10639-10643.
[21] Wei X. H.; Liu X.; Wang X. H.; Xue Y. W.; Yang X. J.; Yang S. D.J Org Chem. 2025, 90, 292-299.
[22] Ren S. M.; Yang W. J.; Ding K.; Kang J.; Zou J. X.; Su B.Org Lett. 2025, 27, 6082-6087.
[23] Sun J.; Ye H.; Sun F.; Pan Y. Y.; Zhu X. W.; Wu X. X.Org Lett. 2023, 25, 5220-5225.
[24] Wang W.-H.; Zhang S.-Y.; Zhang Y.-X.; Wang Y.-Q.; Zhang Q.-W.Journal of the American Chemical Society. 2025, 147, 14797-14805.
[25] Qian D.-W.; Yang J.; Wang G.-W.; Yang S.-D.The Journal of Organic Chemistry. 2023, 88, 3539-3554.
[26] Gu J.; Wu Y.; Tang Z.; Liu S.; Yu B.; Luo J.; Li B.; Wang D.The Journal of Organic Chemistry. 2026, 91, 4776-4786.
[27] Ma Y.; Luo H.; Lin L.Org Lett. 2023, 25, 3492-3496.
[28] Wang X. S.; Ye F.; Xu Z.; Cao J.; Xu L. W.J Org Chem. 2025, 90, 13298-13302.
[29] Rawat N.; Sharma P.; Nasireddy S. R.; Vilas A.; Singh A.J Org Chem. 2025, 90, 8703-8711.
[30] Breger E.;Dussart-Gautheret, J.; Taakili, R.; Fontaine-Vive, F.; Cummins, C. C.; Benhida, R.JACS Au. 2025, 5, 2861-2870.
[31] Liu Z. Z.; Zhang C. J.; Qu J. P.J Org Chem. 2025, 90, 6357-6361.
[32] Zhang K.; Liu J.; Li Y.; Xu Y.; Cai L.Org Lett. 2024, 26, 9056-9061.
[33] Ye L.; Gan Q.; Wang X.; Chen X.; Zhang X.; Liu Y.; Jiang Z.ACS Sustainable Chemistry & Engineering. 2025, 13, 10165-10174.
[34] Yang W. T.; Nie X. K.; Huang J.; Zhang S. Q.; Cui X.; Tang Z.; Li G. X.Org Lett. 2025, 27, 6884-6889.
[35] Liu C.; Zhang Y.; Gu X.; Huang N.; Zhang M.; Jiang J.Org Lett. 2024, 26, 10594-10599.
[36] Guo J.; Zhang Y.; Li M.-M.; Zhang A.; Yang H.; Min H.; Ding W.Organic Letters. 2024, 26, 10176-10182.
[37] Pagire S. K.; Shu C.; Reich D.; Noble A.; Aggarwal V. K.Journal of the American Chemical Society. 2023, 145, 18649-18657.
[38] Xiong W.; He J.; Liu J.; Chen P.; Xu S.; Liu Y.; Chen S.; You Y.; Chen Z.; Zhao J.Organic Chemistry Frontiers. 2024, 11, 6287-6292.
[39] Yin J.; Lin X.; Chai L.; Wang C.-Y.; Zhu L.; Li C.Chem. 2023, 9, 1945-1954.
[40] Wang J.; Zhang Y.; Zhu L.; Xue X.-S.; Li C.Angewandte Chemie International Edition. 2024, 63, e202400856.
[41] Cheng Y.; Zhen J.; Chai L.; Wang J.; Yin J.; Zhu L.; Li C.Angewandte Chemie International Edition. 2024, 63, e202316764.
[42] Wei X. H.; Xue Y. W.; Jiang X. M.; Quan G. G.; Ye J. Q.; Guo X.; Liu X.Org Lett. 2025, 27, 1124-1129.
[43] Shi D. W.; Li M.; Wang Z. C.; Liu J.; Xin Y. H.; Liu J. R.; Yang S. D.; Yang B.J Org Chem. 2025, 90, 7673-7681.
[44] Shi D. W.; Li M.; Yang R. J.; Zhao X. Y.; Zhang T.; Huangfu J.; Xu L.; Wang K.; Ma Y. X.; Yang B.J Org Chem. 2025, 90, 5578-5585.
[45] Sun H.; Wang J.; Du Z.; Zhang K.; Hu J.; Jing S.Org Lett. 2024, 26, 1618-1622.
[46] Sun B. Q.; Yang J.; Fan L.; Xu Q.; Wang S.; Zhong H.; Xiang H. Y.J Org Chem. 2024, 89, 11739-11746.
[47] Zhuang H.; Wan P.; Miao C.; Yang Y.; Liang S.; Han F.J Org Chem. 2024, 89, 2397-2407.
[48] Yang L.; Wu J.; Li Y.; Tang Y.; Li J.; Xu S.Org Lett. 2024, 26, 3208-3212.
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