从红鸡蛋花叶中分离得到4个新羧基取代苯丙酸类衍生物,plumeriapropionics F-I（1~4）。采用电子圆二色谱（ECD） 计算确定了它们的绝对构型。化合物1~4为少见的羧基取代苯丙酸类衍生物,目前已报道的该类类似物不足10个。采用体外小鼠RAW 264.7巨噬细胞模型,评价了化合物1~4对脂多糖（LPS）诱导一氧化氮（NO）生成的抑制作用。结果显示,化合物1~4均具有显著的抑制活性,IC₅₀范围在5.12 ± 0.08到38.29 ± 0.10 μM之间。作为阳性对照的吲哚美辛对一氧化氮生成的 IC₅₀值为25.11 ± 0.09 μM。

Four new carboxyl-substituted phenylpropanoic acid derivatives, named plumeriapropionics F-I (1-4), were isolated from the leaves of Plumeria rubra L. Compounds 1-4 are rare carboxyl-substituted phenylpropanoic acid derivatives, and fewer than 10 analogues of this type have been reported so far. Their absolute configurations were determined by electronic circular dichroism (ECD) calculations. We evaluated the inhibitory effects of plumeriapropionics F-I on lipopolysaccharide (LPS)-induced nitric oxide (NO) production in mouse macrophage RAW 264.7 cells in vitro. Compounds 1-4 showed potent inhibitory activities, with IC₅₀ values ranging from 5.12 ± 0.08 to 38.29 ± 0.10 μM. For comparison, the positive control indomethacin exhibited an IC₅₀ value of 25.11 ± 0.09 μM against NO production.