Copper-Catalyzed N-Arylations of Nitrogen-Containing Heterocycles in Water

doi:10.6023/cjoc201205018

Chin. J. Org. Chem. ›› 2012, Vol. 32 ›› Issue (08): 1429-1433.DOI: 10.6023/cjoc201205018 Previous Articles Next Articles

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水相中铜催化含氮杂环化合物的N-芳基化反应（封面文章）

张敬先, 殷慧清, 韩世清

南京工业大学生物与制药工程学院南京 211816

收稿日期:2012-05-16 修回日期:2012-06-07 发布日期:2012-06-20
通讯作者: 韩世清 E-mail:hanshiqing@njut.edu.cn
基金资助:
国家自然科学基金(Nos. 20942006, 21072095)资助项目.

Copper-Catalyzed N-Arylations of Nitrogen-Containing Heterocycles in Water

Zhang Jingxian, Yin Huiqing, Han Shiqing

College of Biotechnology and Pharmaceutical Engineering, Nanjing University of Technology, Nanjing 211816

Received:2012-05-16 Revised:2012-06-07 Published:2012-06-20
Supported by:
Project supported by the National Natural Science Foundation of China (Nos. 20942006, 21072095).

A simple, efficient, inexpensive and powerful method for the C—N coupling of nitrogen-containing heterocycles with aryl halides was developed by using cheap Cu₂O as catalyst, inexpensive and readily available 8-hydroxyquinoline as ligand, n-Bu₄NBr as phase transfer catalyst, water as solvent at 100℃. Most products were synthesized in good to excellent yields.

Key words: copper-catalyst, nitrogen-containing heterocycles, N-arylation, aqueous media

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Zhang Jingxian, Yin Huiqing, Han Shiqing. Copper-Catalyzed N-Arylations of Nitrogen-Containing Heterocycles in Water[J]. Chin. J. Org. Chem., 2012, 32(08): 1429-1433.

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水相中铜催化含氮杂环化合物的N-芳基化反应（封面文章）

Copper-Catalyzed N-Arylations of Nitrogen-Containing Heterocycles in Water

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