Zinc-Proline Complex Catalyzed Knoevenagel Condensation in Water

doi:10.6023/cjoc201812046

Chin. J. Org. Chem. ›› 2019, Vol. 39 ›› Issue (5): 1469-1474.DOI: 10.6023/cjoc201812046 Previous Articles Next Articles

Notes

锌-脯氨酸复合物催化的水相Knoevenagel缩合

颜世强^a,b, 郭伟^b, 王文笙^b, 张伟^a

a 复旦大学药学院上海 201203;
b 山东达因海洋生物制药股份有限公司威海 264300

收稿日期:2018-12-26 修回日期:2019-01-16 发布日期:2019-01-31
通讯作者: 张伟 E-mail:zhangw416@fudan.edu.cn
基金资助:
国家自然科学基金（No.81573340）及山东省自主创新及成果转化专项（No.2015ZDXX0302A02）资助项目.

Zinc-Proline Complex Catalyzed Knoevenagel Condensation in Water

Yan Shiqiang^a,b, Guo Wei^b, Wang Wensheng^b, Zhang Wei^a

a School of Pharmacy, Fudan University, Shanghai 201203;
b Shandong Dyne Marine Biopharmaceutical Co., Ltd., Weihai 264300

Received:2018-12-26 Revised:2019-01-16 Published:2019-01-31
Contact: 10.6023/cjoc201812046 E-mail:zhangw416@fudan.edu.cn
Supported by:
Project supported by the National Natural Science Foundation of China (No. 81573340) and the Special Projects for Independent Innovation and Achievement Transformation of Shandong Province (No. 2015ZDXX0302A02).

1. Zinc-Proline Complex Catalyzed Knoevenagel Condensation in Water.PDF(2784KB)

Abstract

Zinc-proline complex catalyzed Knoevenagel condensation in water was reported. Seventeen aldehydes and two ketones were investigated, which coupled with malononitrile smoothly affording desired Knoevenagel condensation products in 5~10 min at 80℃ in the yields of 84%~99%. The catalyst can be recovered and reused for ten cycles without loss of activity.

Key words: Knoevenagel condensation, aqueous media, zinc-proline complex, environmentally benign

Cite this article

Yan Shiqiang, Guo Wei, Wang Wensheng, Zhang Wei. Zinc-Proline Complex Catalyzed Knoevenagel Condensation in Water[J]. Chin. J. Org. Chem., 2019, 39(5): 1469-1474.

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锌-脯氨酸复合物催化的水相Knoevenagel缩合

Zinc-Proline Complex Catalyzed Knoevenagel Condensation in Water

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