Chin. J. Org. Chem. ›› 2012, Vol. 32 ›› Issue (07): 1232-1240.DOI: 10.6023/cjoc1110083 Previous Articles     Next Articles



吴杰群a,b, 刘文b, 张嗣良a   

  1. a 华东理工大学 生物反应器工程国家重点实验室 上海 200237;
    b 中国科学院上海有机化学研究所 生命有机化学国家重点实验室 上海 200032
  • 收稿日期:2011-10-08 修回日期:2012-01-16 发布日期:2012-02-08
  • 通讯作者: 张嗣良

Biosynthesis and Combinatorial Biosynthesis of Erythromycin

Chen Lia,b, Sun Shaofab, Song Gongwua   

  1. a State Key Laboratory of Bioreactor Engineering, East China University of Science and Technology, Shanghai 200237;
    b State Key Laboratory of Bio-Organic and Natural Products Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai 200032
  • Received:2011-10-08 Revised:2012-01-16 Published:2012-02-08

Combinatorial biosynthesis plays a growing role of drug discovery and development in the fields of biology, chemistry and medical sciences. Erythromycin, as the model molecule, has long been appreciated for the investigations into the biosynthesis of natural products and their associated structural diversity by pathway engineering. In this paper the progress regarding erythromycin in biosynthesis and combinatorial biosynthesis is reviewed. The problems and application prospects are also discussed.

Key words: erythromycin, biosynthesis, combinatorial biosynthesis