Application of Boronate Bond in Drug Delivery System

doi:10.6023/cjoc202006060

Abstract

Because of its excellent controlled release properties, stimulus-responsive drug carriers have attracted extensive attention in the field of biomedicine and have achieved extremely rapid development. Boronate bonds have been widely used as a stimulus-responsive site in the construction of drug carriers because of its simple construction conditions, good biocompatibility, and fast responsiveness to various micro-environmental changes such as pH, glucose and 5'-adenosine triphosphate (ATP) concentration in vivo. The types of drug carriers based on boronate bonds include drug-polymer conjugate, polymer micelles, linear-hyperbranched polymers and mesoporous silica, which could load anticancer drugs and deliver insulin and genes. Besides, drugs could be integrated into carrier by covalent bonding, physical encapsulation, and electrostatic interactions, which could be released at specific sites via endogenous stimuli. The application of boronate bond in drug delivery system is reviewed from four aspects: drug types, carrier types, combination mode of drug and carrier as well as breaking mechanism of boronate bond. The main challenges and future advances in this field are also detailed.

Key words: stimulus-responsive, drug carrier, boronate bond

Cite this article

Lijuan Wang, Xianliang Sheng, Jie Wang, Yuhui Zhang. Application of Boronate Bond in Drug Delivery System[J]. Chinese Journal of Organic Chemistry, 2021, 41(2): 567-581.

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Fig. & Tab. 13

Figure 1. Schematic illustration of the formation process of Dex/Chol-PBA nanoassembly and its pH-responsive drug delivery for lysosomal acidity targeting

Figure 2. Schematic illustration of the formation process of DOX/BNPs nanoassembly

Figure 3. Schematic illustration of the formation process of PMAPBA/Dextran nanoassembly

Figure 4. Schematic illustration of the formation process of supramolecular vesicles based on WP5?G supra-amphiphile and their glucose-responsive insulin delivery[28]

Figure 5. Schematic illustration of the formation process of supramolecular vesicles of the host-guest complex WP5?G as well as their insulin and GOx delivery under hyperglycemic state[29]

Figure 6. Schematic illustration for the formation and destruction of pPBA-AND nanoassembly

Figure 7. Schematic illustration for the construction of HAGlu-BTZ polysaccharide conjugates

Figure 8. Schematic illustration of the formation process of the boronate crosslinked micelles (BCM) and its hydrophobic dye or drug delivery in response to mannitol and/or acidic pH values

Figure 9. Schematic illustration of the formation process of dynamically stable mPEG-PBA/HEHDO nanoconstruction

Figure 10. Schematic illustration of the preparation of cross-linked MSN-PAA-AGA and its dual-responsive drug release process

Figure 11. Schematic illustration of preparation of Si-Dox@HA nanoconstruction and its H2O2-responsive Dox release process

Figure 12. Schematic illustration of formation process of ETO-loaded CCLMs and its pH- and Redox-responsive ETO delivery

Figure 13. Schematic illustration of formation of host-guest complexation between α-CD and PBEM as well as its dual stimuli-responsive drug release process

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