Chin. J. Org. Chem. ›› 2013, Vol. 33 ›› Issue (12): 2528-2532.DOI: 10.6023/cjoc201307025 Previous Articles     Next Articles

Articles

宾川乌头根中两个新的二萜生物碱

尹田鹏, 蔡乐, 雷刚, 董建伟, 刘彦雄, 丁中涛   

  1. 教育部自然资源药物化学重点实验室 云南大学化学科学与工程学院 昆明 650091
  • 收稿日期:2013-07-17 修回日期:2013-08-13 发布日期:2013-08-29
  • 通讯作者: 丁中涛 E-mail:ztding@ynu.edu.cn
  • 基金资助:

    国家自然科学基金(No. 21002084)、云南省自然科学基金(No. 2010CD017)和2012年云南大学省级大学生创新创业训练计划资助项目.

Two New Diterpenoid Alkaloids from the Roots of Aconitum duclouxii Levl

Yin Tianpeng, Cai Le, Lei Gang, Dong Jianwei, Liu Yanxiong, Ding Zhongtao   

  1. Key Laboratory of Medicinal Chemistry for Nature Resource, Ministry of Education, School of Chemical Science and Technology, Yunnan University, Kunming 650091
  • Received:2013-07-17 Revised:2013-08-13 Published:2013-08-29
  • Supported by:

    Project supported by the National Natural Science Foundation of China (No. 21002084), the Natural Science Foundation of Yunnan Province (No. 2010CD017), and an Undergraduates Innovative Experiment Project from Yunnan Province.

Two new C-19-diterpenoid alkaloids, ducloudines A (1) and B (2), together with two known alkaloids of 14-acetylneoline (3) and aconitine (4), were isolated from the roots of Aconitum duclouxii Levl. The structures of new alkaloids were established on the basis of spectral data (HR-MS, X-ray crystallographic analysis, 1D-and 2D-NMR). Cytotoxicities of compounds 1 and 2 were tested against five cancer cell lines (HL-60, A549, SMMC-7721, MCF-7, SW480). Results showed that compounds 1 and 2 had no cytotoxic effects on these five tumor cells (IC50 > 40 μmol/L).

Key words: Aconitum duclouxii, diterpenoid alkaloids, ducloudine A, ducloudine B, cytotoxicity