Transition-Metal-Free Alkynylation of Imidazoles with Alkynyl Bromides

doi:10.6023/cjoc201401008

Chin. J. Org. Chem. ›› 2014, Vol. 34 ›› Issue (7): 1352-1357.DOI: 10.6023/cjoc201401008 Previous Articles Next Articles

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无过渡金属催化条件下咪唑衍生物与炔基溴的炔基化反应研究

于敬阳, 彭进松, 岳亦霞, 赵宇卓, 陈春霞

东北林业大学理学院化学化工系哈尔滨 150040

收稿日期:2014-01-07 修回日期:2014-03-25 发布日期:2014-04-15
通讯作者: 陈春霞 E-mail:ccx1759@163.com
基金资助:
黑龙江省教育厅科学技术研究（No.12533023）资助项目.

Transition-Metal-Free Alkynylation of Imidazoles with Alkynyl Bromides

Yu Jingyang, Peng Jinsong, Yue Yixia, Zhao Yuzhuo, Chen Chunxia

Department of Chemistry and Chemical Engineering, College of Science, Northeast Forestry University, Harbin 150040

Received:2014-01-07 Revised:2014-03-25 Published:2014-04-15
Supported by:
Project supported by the Scientific Research Fund of Heilongjiang Provincial Education Department (No. 12533023).

Transition-metal-free alkynylation of imidazoles with alkynyl bromides was examined in detail. With K₂CO₃ as base in N,N-dimethylformamide (DMF) at 80℃ for 12 h, the reaction afforded the corresponding carbon-nitrogen cross-coupling products in moderate yield. Imidazole-based aromatic ynamines were synthesized by the above method, and the structure was characterized by ¹H NMR and ¹³C NMR spectra.

Key words: transition-metal-free, imidazoles, alkynyl bromides, C-N cross-coupling, aromatic ynamines

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Yu Jingyang, Peng Jinsong, Yue Yixia, Zhao Yuzhuo, Chen Chunxia. Transition-Metal-Free Alkynylation of Imidazoles with Alkynyl Bromides[J]. Chin. J. Org. Chem., 2014, 34(7): 1352-1357.

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无过渡金属催化条件下咪唑衍生物与炔基溴的炔基化反应研究

Transition-Metal-Free Alkynylation of Imidazoles with Alkynyl Bromides

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