Chin. J. Org. Chem. ›› 2014, Vol. 34 ›› Issue (6): 1172-1176.DOI: 10.6023/cjoc201401014 Previous Articles     Next Articles


红树尖瓣海莲内生真菌Penicillium sp. J41221的代谢产物及其抗菌活性研究

郑彩娟, 黄国雷, 唐雄肇, 王德能, 龚小路, 张强, 宋小平, 陈光英   

  1. 海南师范大学热带药用植物化学教育部重点实验室 海南师范大学化学与化工学院 海口 571158
  • 收稿日期:2014-01-09 修回日期:2014-01-26 发布日期:2014-02-14
  • 通讯作者: 宋小平, 陈光英
  • 基金资助:

    海南省自然科学基金(No. 213021)、国家自然科学基金(Nos. 81160391,81360478,21162009)、海南省大学生创新训练(No. 2013116580)资助项目.

Secondary Metabolites and Antibacterial Activities of a Bruguiera sexangula var. Rhynchopetala-Derived Fungus Penicillium sp. (J41221)

Zheng Caijuan, Huang Guolei, Tang Xiongzhao, Wang Deneng, Gong Xiaolu, Zhang Qiang, Song Xiaoping, Chen Guangying   

  1. Key Laboratory of Tropical Medicinal Plant Chemistry of Ministry of Education, College of Chemistry and Chemical Engineering, Hainan Normal University, Haikou 571158
  • Received:2014-01-09 Revised:2014-01-26 Published:2014-02-14
  • Supported by:

    Project supported by the Natural Science Foundation of Hainan Province (No. 213021), the National Natural Science Foundation of China (Nos. 81160391, 81360478, 21162009) and the National Undergraduate Innovation Training Programs (No. 2013116580).

Under the guidance of bioassay, four tetracyclic triterpenoids and two steroids were isolated from the fermentation products of Penicillium sp. (J41221), a fungus obtained from a mangrove Bruguiera sexangula var. Rhynchopetala. Their stru- ctures were identified as 11-oxo-12α-acetoxy-4,4-dimethyl-24-methylene-5α-cholesta-8,14-diene-2α,3β-diol (1), 12α- acetoxy- 4,4-dimethyl-24-methylene-5α-cholesta-8-momoene-3β,11β-diol (2), 12α-acetoxy-4,4-dimethyl-24-methylene-5α-cholesta- 8,14-diene-3β,11β-diol (3), 12α-acetoxy-4,4-dimethyl-24-methylene-5α-cholesta-8,14-diene-2α,3β,11β-triol (4), cerevisterol (5) and (3β,5α,6β,22E)-6-methoxyergosta-7,22-diene-3,5-diol (6). Among them, compound 1 was a new naturally occurring compound, and 1 and 2 have no spectroscopic data reported until now. Compounds 2 and 4 showed inhibitory activities against Staphylococcus aureus, Escherichia coli and Micrococcus tetragenu, with minimum inhibitory concentration (MIC) values of 5 and 4.86 μmol/L, respectively.

Key words: Bruguiera sexangula var. Rhynchopetala, Penicillium sp., secondary metabolites, triterpenoids, antibacterial activities