Vilsmeier Reactions of β-Oxo Amide Derivatives：Applications in the Synthesis of Heterocyclic Compounds

doi:10.6023/cjoc201403006

Chin. J. Org. Chem. ›› 2014, Vol. 34 ›› Issue (6): 1037-1047.DOI: 10.6023/cjoc201403006 Previous Articles Next Articles

ACCOUNT

β-氧代酰胺衍生物的Vilsmeier反应在杂环化合物合成中的应用

梁永久^a, 黄鹏^a,b, 张睿^a, 董德文^a

a. 中国科学院长春应用化学研究所长春 130022;
b. 辽宁大学化学院沈阳 110036

收稿日期:2014-03-04 修回日期:2014-03-15 发布日期:2014-03-26
通讯作者: 黄鹏, 董德文 E-mail:huangp019@126.com;dwdong@ciac.ac.cn
基金资助:
国家自然科学基金（Nos. 20872136，21172211）资助项目.

Vilsmeier Reactions of β-Oxo Amide Derivatives：Applications in the Synthesis of Heterocyclic Compounds

Liang Yongjiu^a, Huang Peng^a,b, Zhang Rui^a, Dong Dewen^a

a. Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022;
b. College of Chemistry, Liaoning University, Shenyang 110036

Received:2014-03-04 Revised:2014-03-15 Published:2014-03-26
Supported by:
Project supported by the National Natural Science Foundation of China (Nos. 20872136, 21172211).

Our recent research progress based on Vilsmeier reaction of β-oxo amide derivatives is summarized in this account. Series of functionalized β-oxo amide derivatives were designed and prepared, their reaction under the Vilsmeier reaction conditions and the mechanisms involved in these reactions were investigated. Efficient synthetic approaches for four-, five-, and six-membered heterocycles via Vilsmeier reaction of β-oxo amide derivatives had been developed.

Key words: β-oxo amides, Vilsmeier reaction, heterocycles, synthetic method

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Liang Yongjiu, Huang Peng, Zhang Rui, Dong Dewen. Vilsmeier Reactions of β-Oxo Amide Derivatives：Applications in the Synthesis of Heterocyclic Compounds[J]. Chin. J. Org. Chem., 2014, 34(6): 1037-1047.

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β-氧代酰胺衍生物的Vilsmeier反应在杂环化合物合成中的应用

Vilsmeier Reactions of β-Oxo Amide Derivatives：Applications in the Synthesis of Heterocyclic Compounds

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