Chinese Journal of Organic Chemistry ›› 2022, Vol. 42 ›› Issue (12): 3995-4023.DOI: 10.6023/cjoc202209032 Previous Articles     Next Articles

Special Issue: 自由基化学专辑



赵晓伟a, 夏紫琴a, 张曼b,*(), 周能能a,*()   

  1. a 安徽师范大学化学与材料科学学院 安徽芜湖 241002
    b 安徽师范大学物理与电子信息学院 安徽芜湖 241002
  • 收稿日期:2022-09-26 修回日期:2022-10-24 发布日期:2022-11-07
  • 通讯作者: 张曼, 周能能
  • 基金资助:

Radical-Mediated Tandem Cyclization to Construct Seven-Membered Nitrogen/Oxygen Heterocycles

Xiaowei Zhaoa, Ziqin Xiaa, Man Zhangb(), Nengneng Zhoua()   

  1. a School of Chemistry and Materials Science, Anhui Normal University, Wuhu, Anhui 241002
    b School of Physics and Electronic Information, Anhui Normal University, Wuhu, Anhui 241002
  • Received:2022-09-26 Revised:2022-10-24 Published:2022-11-07
  • Contact: Man Zhang, Nengneng Zhou
  • Supported by:
    National Natural Science Foundation of China(21901006)

Owing to the special chemical structure of the seven-membered heterocyclic skeleton and the unique chemical properties of the heteroatoms contained, it is widely used in natural products and drug molecules. However, the development of synthetic methodology for these structures is challenging due to the unique thermodynamic and kinetic characteristics of nitrogen/oxygen-containing seven-membered heterocyclic frameworks, as well as their own unique cross-ring forces. Therefore, it is of great significance to develop simple and efficient methods for the construction of seven-membered heterocyclic compounds. Compared with traditional synthetic methods, radical reactions can avoid the limitations of poor atom economy and harsh reaction conditions. In this review, the recent synthetic strategies for the construction of seven-membered nitrogen/oxygen-containing heterocyclic compounds using radical tandem cyclization reactions are summarized.

Key words: free radical, cyclization, seven-membered nitrogen heterocycles, seven-membered oxygen heterocycles