Chin. J. Org. Chem. ›› 2015, Vol. 35 ›› Issue (4): 781-788.DOI: 10.6023/cjoc201409046 Previous Articles     Next Articles



谭明雄a,b, 顾运琼a,b, 罗旭健a, 张培a   

  1. a 玉林师范学院化学与材料学院 玉林 537000;
    b 广西师范大学药用资源化学与药物分子工程教育部重点实验室 桂林 541004
  • 收稿日期:2014-10-03 修回日期:2014-10-05 发布日期:2014-12-08
  • 通讯作者: 谭明雄
  • 基金资助:

    国家自然科学基金(No. 21261025)、药用资源化学与药物分子工程教育部重点实验室开放基金(Nos. CMEMR2011-09, CMEMR2014-B08)、广西高校高水平创新团队及卓越学者计划.

Progress in Directed Transition Metal-Catalyzed Oxidation of Inactive C(sp3)—H Bonds

Tan Mingxionga,b, Gu Yunqionga,b, Luo Xujiana, Zhang Peia   

  1. a College of Chemistry and Materials, Yulin Normal University, Yulin 537000;
    b Key Laboratory for the Chemistry and Molecular Engineering of Medicinal Resources, Guangxi Normal University, Guilin 541004
  • Received:2014-10-03 Revised:2014-10-05 Published:2014-12-08
  • Supported by:

    Project supported by the National Natural Science Foundation of China (No. 21261025), the Key Laboratory for the Chemistry and Molecular Engineering of Medicinal Resources, Ministry of Education (Nos. CMEMR2011-09, CMEMR2014-B08), and the Innovative Team & Outstanding Talent Program of Colleges and Universities in Guangxi.

The recent progress in transition metal-catalyzed oxidation of C(sp3)—H bonds has been made. Researches focus on the selective oxidation of methane, as well as the oxidation of methyl groups assisted by chelating directing groups. The researches lead to efficient and highly selective oxidative conversion that are unable to solve by traditional methods. This review covers the effect of directing groups (oxime, oxazoline, pyridine, amide, carboxylic acid, and hydroxyl) on promoting oxidation of C(sp3)—H bonds, the formation of acetylation, hydroxylation, carbonylation, esterification, and metal-catalyzed oxidative reaction system and mechanisms.

Key words: transition metal-catalyzed, inactive C(sp3)—H bonds, oxidation