A Novel Method to Prepare Multisubstituted Pyrazoles

doi:10.6023/cjoc201501037

Chin. J. Org. Chem. ›› 2015, Vol. 35 ›› Issue (3): 625-632.DOI: 10.6023/cjoc201501037 Previous Articles Next Articles

一种构建多取代吡唑的新策略

陈斌, 于丛军, 张国柱

中国科学院上海有机化学研究所金属有机化学国家重点实验室上海 200032

收稿日期:2015-01-27 修回日期:2015-03-03 发布日期:2015-03-04
通讯作者: 张国柱 E-mail:guozhuzhang@sioc.ac.cn
基金资助:
中国科学院上海有机化学研究所基金资助项目.

A Novel Method to Prepare Multisubstituted Pyrazoles

Chen Bin, Yu Congjun, Zhang Guozhu

State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Science, Shanghai 200032

Received:2015-01-27 Revised:2015-03-03 Published:2015-03-04
Supported by:
Project supported by the Foundation of Shanghai Institute of Organic Chemistry, Chinese Academy of Science.

1. A Novel Method to Prepare Multisubstituted Pyrazoles.PDF(1507KB)

Abstract

This paper reports a new strategy to construct multisubstituted pyrazoles from hydrazine and 1,3-diketone which is generated through α-oxo gold carbene using readily available propargyl alcohol. The carbene formation and C—C bond migration could be applied in a tandem process, connected by a carbene cyclization, leading to complex diketone products.

Key words: gold catalysis, pyrazole, gold carbene, polycyclic, tandem process

Cite this article

Chen Bin, Yu Congjun, Zhang Guozhu. A Novel Method to Prepare Multisubstituted Pyrazoles[J]. Chin. J. Org. Chem., 2015, 35(3): 625-632.

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一种构建多取代吡唑的新策略

A Novel Method to Prepare Multisubstituted Pyrazoles

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