Progress in the Synthesis of Spirotryprostatin Alkaloids

doi:10.6023/cjoc201603031

Chin. J. Org. Chem. ›› 2016, Vol. 36 ›› Issue (10): 2380-2396.DOI: 10.6023/cjoc201603031 Previous Articles Next Articles

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Spirotryprostatin类生物碱的合成研究进展

马养民, 范超

陕西科技大学化学与化工学院教育部轻化工助剂化学与技术重点实验室西安 710021

收稿日期:2016-03-18 修回日期:2016-05-17 发布日期:2016-06-01
通讯作者: 马养民,E-mail:mym63@sina.com E-mail:mym63@sina.com
基金资助:
陕西省教育厅重点实验室（No.2010JS056）资助项目.

Progress in the Synthesis of Spirotryprostatin Alkaloids

Ma Yangmin, Fan Chao

Key Laboratory of Auxiliary Chemistry & Technology for Chemical Industry, Ministry of Education, College of Chemistry & Chemical Engineering, Shaanxi University of Science & Technology, Xi'an 710021

Received:2016-03-18 Revised:2016-05-17 Published:2016-06-01
Supported by:
Project supported by the Scientific Research Project Item for Key Laboratory of Shaanxi Province Education Department (No.2010JS056).

Spirotryprostatin is one of the alkaloids which contains the spiro-indolyl diketopiperazine structure. It is structurally characterized by indole moiety connected to diketopiperazine moiety via the spiro quaternary carbon chiral center. The combination of the structure of spiro-indoyl and diketopiperazine has demonstrated the special physiological and pharmacological activities, especially the excellent inhibitory activity to cell cycle. In recent years, The synthesis of spirotryprostatin has attracted much attention, according to the formation of the spirocyclic chiral center. The total synthetic efforts towards spirotryprostatin alkaloids are presented.

Key words: spirotryprostatin, spiro-indolyl diketopiperazine, alkaloid, biological activity, total synthesis

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Ma Yangmin, Fan Chao. Progress in the Synthesis of Spirotryprostatin Alkaloids[J]. Chin. J. Org. Chem., 2016, 36(10): 2380-2396.

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Spirotryprostatin类生物碱的合成研究进展

Progress in the Synthesis of Spirotryprostatin Alkaloids

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