Chin. J. Org. Chem. ›› 2017, Vol. 37 ›› Issue (3): 720-725.DOI: 10.6023/cjoc201609033 Previous Articles     Next Articles



安艳妮, 李建晓, 李蒙, 李春生, 杨少容   

  1. 华南理工大学化学与化工学院 广州 510640
  • 收稿日期:2016-09-29 修回日期:2016-11-07 发布日期:2016-11-17
  • 通讯作者: 杨少容,
  • 基金资助:


N-Iodosuccinimide-Promoted Regioselective Arylsulfenylation of Imidazo[1,2-a]pyridines with Disulfides

An Yanni, Li Jianxiao, Li Meng, Li Chunsheng, Yang Shaorong   

  1. School of Chemistry and Chemical Engineering, South China University of Technology, Guangzhou 510640
  • Received:2016-09-29 Revised:2016-11-07 Published:2016-11-17
  • Contact: 10.6023/cjoc201609033
  • Supported by:

    Project supported by the National Natural Science Foundation of China (No. 21502055), the Fundamental Research Funds for the Central Universities (No. 2015ZM150) and the China Postdoctoral Science Foundation (Nos. 2015M572303, 2016T90779).

An efficient and practical N-iodosuccinimide-promoted regioselective arylsulfenylation of imidazo[1,2-a]pyridines with disulfides has been developed to afford functionalized 3-sulfenylimidazo[1,2-a]pyridines heterocycles in moderate to good yields. Their structures were confirmed by IR, 1H NMR, 13C NMR and HRMS. Furthermore, this method has the advantages of mild reaction conditions, broad substrates scope and environmentally benign. Notably, the current methodology could also be conveniently applied to the synthesis of thioarylated naturally occurring biologically active frameworks.

Key words: N-iodosuccinimide, ionic liquids, imidazo[1,2-a]pyridines, disulfides, arylsulfenylation