Synthesis and Antitumor Activity of N-Triazol-5-yl-oxazolidin-4-one Derivatives

doi:10.6023/cjoc201701053

Chin. J. Org. Chem. ›› 2017, Vol. 37 ›› Issue (9): 2435-2441.DOI: 10.6023/cjoc201701053 Previous Articles Next Articles

Notes

N-三氮唑基噁唑烷酮类衍生物合成及抗肿瘤活性研究

罗睿^a, 郭山春^b, 郑时龙^b, 王光迪^b, 包旭^a, 何菱^a

a 四川大学华西药学院成都 610041;
b RCMI Cancer Research Center, Xavier University of Louisiana, New Orleans, LA 70125, USA

收稿日期:2017-02-06 修回日期:2017-03-27 发布日期:2017-05-02
通讯作者: 何菱 E-mail:lhe2001@sina.com
基金资助:
川大-泸州战略合作（No.2013CDLZ-S18）和NIMHD-RCMI（No.5G12MD007595）资助项目.

Synthesis and Antitumor Activity of N-Triazol-5-yl-oxazolidin-4-one Derivatives

Luo Rui^a, Guo Shanchun^b, Zheng Shilong^b, Wang Guangdi^b, Bao Xu^a, He Ling^a

a West China School of Pharmacy, Sichuan University, Chengdu, 610041;
b RCMI Cancer Research Center, Xavier University of Louisiana, New Orleans, LA 70125, USA

Received:2017-02-06 Revised:2017-03-27 Published:2017-05-02
Contact: 10.6023/cjoc201701053 E-mail:lhe2001@sina.com
Supported by:
Project supported by the Sichuan University-Lu Zhou Strategic Cooperation Projects (No. 2013CDLZ-S18), the NIH RCMI Program at Xavier University of Louisiana through Grant (No. 2G12MD007595-07).

1. Synthesis and Antitumor Activity of N-Triazol-5-yl-oxazolidin-4-one Derivatives.PDF(1202KB)

Abstract

Fifteen novel N-triazol-5-yl-oxazolidin-4-ones were synthesized through a few of steps from the benzaldehydes. It was found that N-iodosuccinimide (NIS) can promote intramolecular amination reaction which is the key step of the syntheses, which will be used as new method for the intramolecular formation of nitrogen-containing heterocycles. Part of the compounds were evaluated for their anticancer activity. Among them, compounds 6a, 6b and 6c showed moderate antiprolifiration activity toward human breast cancer cells MDA-MB-231 cell lines, while the mild activity of 6a, 6b and 6d against human cervical cancer HeLa cell lines was confirmed in vitro assay.

Key words: N-triazol-5-yl-oxazolidin-4-one, N-iodosuccinimide, intramolecular amination, antitumor activity

Cite this article

Luo Rui, Guo Shanchun, Zheng Shilong, Wang Guangdi, Bao Xu, He Ling. Synthesis and Antitumor Activity of N-Triazol-5-yl-oxazolidin-4-one Derivatives[J]. Chin. J. Org. Chem., 2017, 37(9): 2435-2441.

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N-三氮唑基噁唑烷酮类衍生物合成及抗肿瘤活性研究

Synthesis and Antitumor Activity of N-Triazol-5-yl-oxazolidin-4-one Derivatives

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