Chin. J. Org. Chem. ›› 2017, Vol. 37 ›› Issue (7): 1613-1628.DOI: 10.6023/cjoc201703020 Previous Articles     Next Articles



朱龙志, 曹鑫, 李优, 刘婷, 王勰, 邱仁华, 尹双凤   

  1. 湖南大学化学化工学院 长沙 410082
  • 收稿日期:2017-03-09 修回日期:2017-04-17 发布日期:2017-05-10
  • 通讯作者: 邱仁华, 尹双凤;
  • 基金资助:


Recent Advances on the C-H Bond Functionalization on C(5) Position of 8-Aminoquinolines

Zhu Longzhi, Cao Xin, Li You, Liu Ting, Wang Xie, Qiu Renhua, Yin ShuangFeng   

  1. College of Chemistry and Chemical Engineering, Hunan University, Changsha 410082
  • Received:2017-03-09 Revised:2017-04-17 Published:2017-05-10
  • Contact: 10.6023/cjoc201703020;
  • Supported by:

    Project supported by the National Natural Science Foundation of China (Nos.21373003,21676076),the Natural Science Foundation of Hunan Province (No.2016JJ3034) and the Huann Youth Talent (No.2016RS3023).

8-Aminoquinolines are important nitrogen-containing heterocycles widely existing in the natural products, bio-active molecules and agrochemicals. It has been developed as significant bidentate directing groups or as ligand auxiliary in various kinds of organic reactions, especially in the area of C-H bond functionalization. Therefore, the synthesis of such motifs, especially those with substituted quinolines is of great significance. This review focuses on the remote C-H bond functionalizaitons of 8-aminoquinolines on the C(5) position, including the advantages and disadvantages as well as an outlook in this field.

Key words: C-H bond functionalization, 8-aminoquinoline, remote C-H activation, C(5) position of aminoquinoline