Anthraquinones from the Leaves of Saprosma hainanense

doi:10.6023/cjoc201310014

Chin. J. Org. Chem. ›› 2014, Vol. 34 ›› Issue (3): 522-525.DOI: 10.6023/cjoc201310014 Previous Articles Next Articles

Articles

海南染木树叶中的蒽醌成分研究

王燕, 陈文豪, 陈光英, 宋小平, 张大帅, 傅波, 陈怡

海南师范大学化学与化工学院热带药用植物化学教育部重点实验室海口 571158

收稿日期:2013-10-14 修回日期:2013-11-13 发布日期:2013-11-21
通讯作者: 陈光英 E-mail:chgying123@163.com
基金资助:
国家自然科学基金（Nos. 21162009，31360069）；973计划前期研究专项课题（No. 2011CB512010）；国家级大学生创新训练（No. 201311658019）资助项目.

Anthraquinones from the Leaves of Saprosma hainanense

Wang Yan, Chen Wenhao, Chen Guangying, Song Xiaoping, Zhang Dashuai, Fu Bo, Chen Yi

Key Laboratory of Tropical Medicinal Plant Chemistry of Ministry of Education, College of Chemistry and Chemical Engineering, Hainan Normal University, Haikou 571158

Received:2013-10-14 Revised:2013-11-13 Published:2013-11-21
Supported by:
Project supported by the National Natural Science Foundation of China (Nos. 21162009, 31360069), the 973 Research Program of the Ministry of Science and Technology of China (No. 2011CB512010), and the National Undergraduate Innovation Training Programs (No. 201311658019).

1. Anthraquinones from the Leaves of Saprosma hainanense.PDF(338KB)

Abstract

Nine anthraquinones were isolated from the leaves of Saprosma hainanense. On the basis of spectroscopic data analyses (HRESIMS, 1D-and 2D-NMR) and that reported in the literature, The structures were established as 7-hydroxy-1,2-dimethoxy-6-methylanthraquinone (1), 1-hydroxy-3,6-dimethoxyanthraquinone (2), 10,10'-bianthrone (3), 9,10-anthraquinone (4), rubiadin (5), ramnacanthol (6), 2-hydroxy-3-methyl-9,10-anthraquinone (7), 3-hydroxy-1,2-dimethoxyanthraquinone (8) and 3-hydroxy-1-methoxy-2-carbomethoxy-9,10-anthraquinone (9). Among them, compounds 1 and 2 were new natural products, and 1 has no spectroscopic data reported until now. All compounds except 9 were isolated from this genus for the first time. Compounds 2 and 9 showed stronger inhibitory activities to the most of the bacteria, especially to the Staphylococcus aureus, with the minimum inhibitory concentration (MIC) values of 0.087 μg/mL. Compounds 1 and 6 exhibited the higher inhibitory activities against Bacillus subtilis and Staphylococcus aureus than positive control ciprofloxacin.

Key words: Saprosma hainanense, chemical constituents, anthraquinones, antibacterial activity

Cite this article

Wang Yan, Chen Wenhao, Chen Guangying, Song Xiaoping, Zhang Dashuai, Fu Bo, Chen Yi. Anthraquinones from the Leaves of Saprosma hainanense[J]. Chin. J. Org. Chem., 2014, 34(3): 522-525.

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海南染木树叶中的蒽醌成分研究

Anthraquinones from the Leaves of Saprosma hainanense

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