Chin. J. Org. Chem. ›› 2018, Vol. 38 ›› Issue (8): 2085-2092.DOI: 10.6023/cjoc201801043 Previous Articles     Next Articles



林桂汕a, 陈智聪a, 段文贵a, 王晓宇a, 雷福厚b   

  1. a 广西大学化学化工学院 南宁 530004;
    b 广西林产化学与工程重点实验室 南宁 530008
  • 收稿日期:2018-01-29 修回日期:2018-03-12 发布日期:2018-04-12
  • 通讯作者: 段文贵
  • 基金资助:


Synthesis and Biological Activity of Novel Myrtenal-Derived 2-Acyl-1,2,4-triazole-3-thione Compounds

Lin Guishana, Chen Zhiconga, Duan Wenguia, Wang Xiaoyua, Lei Fuhoub   

  1. a College of Chemistry and Chemical Engineering, Guangxi University, Nanning 530004;
    b Guangxi Key Laboratory of Chemistry and Engineering of Forest Products, Nanning 530008
  • Received:2018-01-29 Revised:2018-03-12 Published:2018-04-12
  • Contact: 10.6023/cjoc201801043
  • Supported by:

    Project supported by the National Natural Science Foundation of China (No. 31460173) and the Open Fund of Guangxi Key Laboratory of Chemistry and En-gineering of Forest Products (No. GXFC16-03).

Sixteen novel myrtenal-derived 2-acyl-1,2,4-triazole-3-thione compounds were designed and synthesized in search of new bioactive compounds. Their structures were confirmed by FTIR, NMR, ESI-MS and elemental analysis. The in vitro antifungal and herbicidal activities of the target compounds were preliminarily evaluated. Some target compounds exhibited favourable antifungal activity at 50 mg/L. Myrtenal-derived 2-(p-methylbenzoyl)-1,2,4-triazole-3-thione (7i) held 83.7% and 72.5% inhibition rates against corn southern leaf blight (Bipolaris maydis) and apple root spot (Physalospora piricola), respectively, and myrtenal-derived 2-(3',5'-dimethylbenzoyl)-1,2,4-triazole-3-thione (7j) had 72.5% inhibition rate against P. piricola (the positive control commercial fungicide chlorothalonil with growth inhibition rates of 90.4% and 75.0% against B. maydis and P. piricola, respectively). Besides, most of the target compounds displayed excellent herbicidal activity against the root-growth of rape (Brassica. campestris). At 100 mg/L, 15 compounds held growth inhibition rates in the range of 80.2%~99.1%, exhibiting much better herbicidal activity than that of the commercial herbicide flumioxazin (positive control) with 63.0% growth inhibition rate.

Key words: myrtenal, α-pinene, 1,2,4-triazole-3-thione, biological activity