Trityl Ion-Mediated Oxidative C—H Alkynylation of 1, 2-Dihydroquinolines

doi:10.6023/cjoc201803001

Chin. J. Org. Chem. ›› 2018, Vol. 38 ›› Issue (5): 1261-1266.DOI: 10.6023/cjoc201803001 Previous Articles Next Articles

Special Issue: 碳氢活化合辑2018-2019

Notes

碳正离子介导的二氢喹啉的氧化碳氢炔基化

刘子强^a, 赵冉^a, 贺妮^a, 李伟^a

山东中医药大学药学院济南 250355

收稿日期:2018-03-01 修回日期:2018-03-16 发布日期:2018-04-13
通讯作者: 李伟,E-mail:liwei6911@163.com E-mail:liwei6911@163.com

Trityl Ion-Mediated Oxidative C—H Alkynylation of 1, 2-Dihydroquinolines

Liu Ziqiang^a, Zhao Ran^a, He Ni^a, Li Wei^a

Department of Pharmaceutical, Shandong University of Traditional Chinese Medicine, Jinan 250355

Received:2018-03-01 Revised:2018-03-16 Published:2018-04-13
Contact: 10.6023/cjoc201803001 E-mail:liwei6911@163.com

1. Trityl Ion-Mediated Oxidative C—H Alkynylation of 1, 2-Dihydroquinolines.PDF(681KB)

Abstract

An efficient synthesis of α-substituted 1, 2-dihydroquinoline compounds through the oxidative C—H functionalization of N-acyl-dihydroquinoline with diverse organoboron reagents mediated by triphenylcarbium perchlorate (Ph₃CClO₄) is reported. The reaction exhibits good functional group tolerance, allowing for C—H alkynylation and alkenylation proceeding smoothly in good yields.

Key words: dihydroquinoline, hydrocarbon functionalization, alkynylation, carbocation, oxidation

Cite this article

Liu Ziqiang, Zhao Ran, He Ni, Li Wei. Trityl Ion-Mediated Oxidative C—H Alkynylation of 1, 2-Dihydroquinolines[J]. Chin. J. Org. Chem., 2018, 38(5): 1261-1266.

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碳正离子介导的二氢喹啉的氧化碳氢炔基化

Trityl Ion-Mediated Oxidative C—H Alkynylation of 1, 2-Dihydroquinolines

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