Chin. J. Org. Chem. ›› 2018, Vol. 38 ›› Issue (11): 2879-2887.DOI: 10.6023/cjoc201805013 Previous Articles     Next Articles

Special Issue: 有机小分子-金属协同催化



殷晓婷, 李文炅, 赵保丽, 程凯   

  1. 绍兴文理学院 浙江省精细化学品传统工艺替代技术研究重点实验室 绍兴 312000
  • 收稿日期:2018-05-03 修回日期:2018-06-11 发布日期:2018-07-16
  • 通讯作者: 程凯
  • 基金资助:


Research Progress on Silver-Catalyzed Decarboxylative Coupling Reaction

Yin Xiaoting, Li Wenjiong, Zhao Baoli, Cheng Kai   

  1. Zhejiang Key Laboratory of Alternative Technologies for Fine Chemicals Process, Shaoxing University, Shaoxing 312000
  • Received:2018-05-03 Revised:2018-06-11 Published:2018-07-16
  • Supported by:

    Project supported by the National Natural Science Foundation of China (No. 21402123), the Zhejiang Provincial Natural Science Foundation (No. LY18B020006, LQ15B020002) and the Science Technology Project of Shaoxing City (No. 2017B70053).

Transition-metal-catalyzed decarboxylative cross-coupling reactions have been well developed as efficient synthetic methods in organic synthesis. Herein the new application of silver-catalyzed decarboxylation in Hunsdiecker-type halogenation, carbon-carbon bond formation, carbon-heteratom bond formation and C-H bond functionalization reaction is discussed. The recent progress in silver-catalyzed decarboxylative coupling reaction with aliphatic carboxylic acids, α-keto acids and aryl carboxylic acid is reviewed. With the assistance of peroxides, selective decarboxylative coupling reaction could be proceeded via free-radical process by silver catalysis. The controlled free-radical transformation is operational simplification without the exclusion of water and oxygen under mild conditions.

Key words: silver-catalyzed, aliphatic carboxylic acid, α-keto acid, aryl carboxylic acid, coupling reacion, free-radical process