Chinese Journal of Organic Chemistry ›› 2020, Vol. 40 ›› Issue (3): 740-747.DOI: 10.6023/cjoc201907040 Previous Articles     Next Articles


皮超, 曲亚平, 崔秀灵, 吴养洁   

  1. 郑州大学化学学院 河南省化学生物与有机化学重点实验室 河南省高等学校应用化学重点开放实验室 郑州 450052
  • 收稿日期:2019-07-26 修回日期:2019-10-23 发布日期:2019-11-01
  • 通讯作者: 崔秀灵, 吴养洁;
  • 基金资助:

Silver-Catalyzed C—H Alkylation of 2-Arylindoles with Maleimides

Pi Chao, Qu Yaping, Cui Xiuling, Wu Yangjie   

  1. Henan Key Laboratory of Chemical Biology and Organic Chemistry, Key Laboratory of Applied Chemistry of Henan Universities, College of Chemistry, Zhengzhou University, Zhengzhou 450052
  • Received:2019-07-26 Revised:2019-10-23 Published:2019-11-01
  • Supported by:
    Project supported by the Key International Cooperation Projects from Chinese Ministry of Science and Technology (No. 2016YFE0132600).

A highly efficient and regioselective C-3-alkylation of 2-arylindoles with maleimides has been developed using Ag(I) as catalyst. 3-(2-Aryl-1H-indol-3-yl)pyrrolidine-2,5-diones were afforded with high yields (up to 97%) under relatively mild reaction conditions. The method features operational simplicity and avoiding external oxidant.

Key words: silver-catalyzed, 2-arylindoles, maleimides, alkylation