Synthesis and Insecticidal Activity of Terpinen-4-ol Derivatives Containing Oxime Ether

doi:10.6023/cjoc201812039

Chin. J. Org. Chem. ›› 2019, Vol. 39 ›› Issue (7): 2070-2074.DOI: 10.6023/cjoc201812039 Previous Articles Next Articles

Notes

含肟醚的松油烯-4-醇衍生物的合成及杀虫活性

雷鹏, 丁新吉, 吴远勇, 马志卿

西北农林科技大学植物保护学院杨凌 712100

收稿日期:2018-12-21 修回日期:2019-01-21 发布日期:2019-03-29
通讯作者: 马志卿 E-mail:mazhiqing2000@126.com
基金资助:
国家自然科学基金（No.31572029）、西北农林科技大学科研启动费（No.00200-Z109021809）资助项目.

Synthesis and Insecticidal Activity of Terpinen-4-ol Derivatives Containing Oxime Ether

Lei Peng, Ding Xinji, Wu Yuanyong, Ma Zhiqing

College of Plant Protection, Northwest A & F University, Yangling 712100

Received:2018-12-21 Revised:2019-01-21 Published:2019-03-29
Contact: 10.6023/cjoc201812039 E-mail:mazhiqing2000@126.com
Supported by:
Project supported by the National Natural Science Foundation of China (No. 31572029) and the Starting Research Fund from the Northwest A&F University (No. 00200-Z109021809).

1. Synthesis and Insecticidal Activity of Terpinen-4-ol Derivatives Containing Oxime Ether.PDF(1568KB)

Abstract

In order to discover high activity lead compound, based on our previous studies, a series of terpinen-4-ol deri- vatives containing oxime ether were designed and synthesized. The bioassay results showed that the target compounds displayed good insecticidal activity against Mythimna separata (Walker). Especially, compound 3a exhibited satisfied activity with the LD₅₀ value of 0.0054 mg/insect, which is 19.1 times than terpinen-4-ol. As a high activity compound with simple structure, 2-methyl-5-(prop-1-en-2-yl)cyclohex-2-en-1-one O-prop-2-yn-1-yl oxime (3a) could be a lead compound for further study.

Key words: oxime ether, terpinen-4-ol, natural product, biological activity, Mythimna separata

Cite this article

Lei Peng, Ding Xinji, Wu Yuanyong, Ma Zhiqing. Synthesis and Insecticidal Activity of Terpinen-4-ol Derivatives Containing Oxime Ether[J]. Chin. J. Org. Chem., 2019, 39(7): 2070-2074.

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含肟醚的松油烯-4-醇衍生物的合成及杀虫活性

Synthesis and Insecticidal Activity of Terpinen-4-ol Derivatives Containing Oxime Ether

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