Recent Advances in Direct C-H Bond Functionalization of Phenylalanine Derivatives

doi:10.6023/cjoc201901029

Chin. J. Org. Chem. ›› 2019, Vol. 39 ›› Issue (7): 1867-1874.DOI: 10.6023/cjoc201901029 Previous Articles Next Articles

Special Issue: 碳氢活化合辑2018-2019

Reviews

苯丙氨酸衍生物的碳氢键直接官能化反应进展

李小芳, 熊伟康, 丁秋平

江西师范大学化学化工学院功能有机小分子教育部重点实验室南昌 330022

收稿日期:2019-01-19 修回日期:2019-02-17 发布日期:2019-03-08
通讯作者: 丁秋平 E-mail:dqpjxnu@gmail.com
基金资助:
国家自然科学基金（No.21662017）资助项目.

Recent Advances in Direct C-H Bond Functionalization of Phenylalanine Derivatives

Li Xiaofang, Xiong Weikang, Ding Qiuping

College of Chemistry and Chemical Engineering, Jiangxi Normal University, Key Laboratory of Small Functional Organic Molecule, Ministry of Education, Nanchang 330022

Received:2019-01-19 Revised:2019-02-17 Published:2019-03-08
Contact: 10.6023/cjoc201901029 E-mail:dqpjxnu@gmail.com
Supported by:
Project supported by the National Natural Science Foundation of China (No. 21662017).

Phenylalanine derivatives are widely found in a broad range of pharmaceutical molecules and exhibit significant biological activity. Direct C-H bond functionalization of phenylalanine derivatives to offer an efficient approach to construct C-I, C(sp²)-C(sp²), C(sp²)-C(sp), C(sp²)-C(sp³), C-N, C-B and C-O bonds is described. The transformation involves ortho-C-H bond iodination and the following intramolecular amination, ortho-alkylation, ortho-arylation, ortho-alkenylation, ortho-alkynylation, ortho-acylation, ortho-acetoxylation, ortho-amination, ortho-boronation, meta-arylation and meta-alky-lation.

Key words: phenylalanine, C-H functionalization, alkylation, alkenylation, arylation

Cite this article

Li Xiaofang, Xiong Weikang, Ding Qiuping. Recent Advances in Direct C-H Bond Functionalization of Phenylalanine Derivatives[J]. Chin. J. Org. Chem., 2019, 39(7): 1867-1874.

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苯丙氨酸衍生物的碳氢键直接官能化反应进展

Recent Advances in Direct C-H Bond Functionalization of Phenylalanine Derivatives

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