Synthesis of Pentafluoroethylated Pyridines via Cu-Catalyzed[3+3] Cycloaddition Reaction of Oxime Acetates

doi:10.6023/cjoc201902025

Chin. J. Org. Chem. ›› 2019, Vol. 39 ›› Issue (6): 1623-1629.DOI: 10.6023/cjoc201902025 Previous Articles Next Articles

Special Issue: 金属有机化学

Articles

铜催化肟酯参与的[3+3]环加成反应合成4-五氟乙基取代的吡啶类化合物

杨思琪, 李鑫, 彭卓金, 于文艳, 王光续, 靳雅兰, 郑冰冰, 代洪雪, 白大昌

河南师范大学化学化工学院新乡 453007

收稿日期:2019-02-23 修回日期:2019-05-16 发布日期:2019-05-28
通讯作者: 白大昌 E-mail:baidachang@126.com
基金资助:
国家自然科学基金（No.21801067）、河南省优势学科（No.510103411009）、河南省高等学校重点科研项目计划（No.18A150010）、河南师范大学启动经费（No.qd17108）资助项目.

Synthesis of Pentafluoroethylated Pyridines via Cu-Catalyzed[3+3] Cycloaddition Reaction of Oxime Acetates

Yang Siqi, Li Xin, Peng Zhuojin, Yu Wenyan, Wang Guangxu, Jin Yalan, Zheng Bingbing, Dai Hongxue, Bai Dachang

a Henan Key Laboratory of Organic Functional Molecule and Drug Innovation, School of Chemistry and Chemical Engineering, Henan Normal University, Xinxiang 453007

Received:2019-02-23 Revised:2019-05-16 Published:2019-05-28
Contact: 10.6023/cjoc201902025 E-mail:baidachang@126.com
Supported by:
Project supported by the National Natural Science Foundation of China (No. 21801067), the Research Fund from Henan Normal University (No. 5101034011009), the Natural Science Research Program of Education Department of Henan Province (No. 18A150010), and the Start-Up Fund from Henan Normal University (No. qd17108).

1. Synthesis of Pentafluoroethylated Pyridines via Cu-Catalyzed[3+3] Cycloaddition Reaction of Oxime Acetates.PDF(1012KB)

Abstract

An improved method for the synthesis of pentafluoroethylated pyridines through Cu-catalyzed[3+3] cyclo-addition reaction of oxime acetates is reported. The starting materials are more readily available, and these reactions occurred under mild conditions with broad substrate scope and excellent regioselectivity. Mechanistic studies have also been preformed.

Key words: pentafluoroethylated, pyridines, copper-catalyzed, oxime acetates

Cite this article

Yang Siqi, Li Xin, Peng Zhuojin, Yu Wenyan, Wang Guangxu, Jin Yalan, Zheng Bingbing, Dai Hongxue, Bai Dachang. Synthesis of Pentafluoroethylated Pyridines via Cu-Catalyzed[3+3] Cycloaddition Reaction of Oxime Acetates[J]. Chin. J. Org. Chem., 2019, 39(6): 1623-1629.

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铜催化肟酯参与的[3+3]环加成反应合成4-五氟乙基取代的吡啶类化合物

Synthesis of Pentafluoroethylated Pyridines via Cu-Catalyzed[3+3] Cycloaddition Reaction of Oxime Acetates

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