Chinese Journal of Organic Chemistry ›› 2020, Vol. 40 ›› Issue (5): 1323-1330.DOI: 10.6023/cjoc201910038 Previous Articles     Next Articles


罗亮, 曹晓梅, 赖国伟, 刘金香, 罗海清, 路东亮, 张勇   

  1. 赣南师范大学有机药物化学重点实验室 江西赣州 341000
  • 收稿日期:2019-10-29 修回日期:2020-01-14 发布日期:2020-02-15
  • 通讯作者: 张勇
  • 基金资助:

“On Water” Nucleophilic Addition of Pyrazolones to Trifluoromethyl Ketones

Luo Liang, Cao Xiaomei, Lai Guowei, Liu Jinxiang, Luo Haiqing, Lu Dongliang, Zhang Yong   

  1. Key Laboratory of Organo-pharmaceutical Chemistry, Gannan Normal University, Ganzhou, Jiangxi 341000
  • Received:2019-10-29 Revised:2020-01-14 Published:2020-02-15
  • Supported by:
    Project supported by the National Natural Science Foundation of China (No. 21562003), the Jiangxi Provincial Department of Science and Technology Fund (20192BAB213007 and 20144BAB2130003), and the Education Department of Jiangxi Province (No. GJJ170835).

A green and efficient nucleophilic addition reaction of trifluoromethyl ketone with pyrazolone was developed under "on water" conditions, affording pyrazolone substituted tertiary trifluoromethyl alcohols in high yields. The advantages of being catalyst-free, column chromatography-free, environmentally benign and easy workup make it a promising method for preparation of a variety of pyrazolone substituted tertiary trifluoromethyl alcohols.

Key words: “on water” reaction, nucleophilic addition, pyrazolone, trifluoromethyl ketone