Chinese Journal of Organic Chemistry ›› 2020, Vol. 40 ›› Issue (6): 1502-1513.DOI: 10.6023/cjoc202001011 Previous Articles     Next Articles


贾乾发, 李娅琼, 林银河   

  1. 长江师范学院化学化工学院 重庆市无机特种功能材料重点实验室 重庆涪陵 408100
  • 收稿日期:2020-01-06 修回日期:2020-02-16 发布日期:2020-03-04
  • 通讯作者: 林银河
  • 基金资助:

Recent Advances in Organocatalyzed Aromatization Reactions

Jia Qianfa, Li Yaqiong, Lin Yinhe   

  1. Chongqing Key Laboratory of Inorganic Special Functional Materials, College of Chemistry and Chemical Engineering, Yangtze Normal University, Fuling, Chongqing 408100
  • Received:2020-01-06 Revised:2020-02-16 Published:2020-03-04
  • Supported by:
    Project supported by the Yangtze Normal University (Nos. 2017KYQD123, 2018QNRC17).

Aromatic compounds possess a particular fragrance and are widely present in natural products and pharmaceuticals. Among them, benzenes are the most abundant substructures of commercially available small-molecule drugs. Therefore, a variety of synthetic methodologies for the construction of aromatic compounds have been pursued vigorously and some significant progresses have been achieved. The dominant methods are transition metal-catalyzed benzannulation of enynes with alkynes to construct the functionalized benzenes. The synthesis of substituted benzene derivatives receives constant attentions since the formation and development of organocatalysis. Compared to metal catalysis, the organocatalytic benzannulation reaction avoids the introduction of a direct group into the pre-existed arene ring and appears to be tolerant of a broad range of substrates. While organocatalysis has emerged as a promising green and effieient synthetic tool and attracted a great deal of attention from synthetic chemists. The development of organocatalyzed aromatization reactions from acyclic starting materials is featured.

Key words: organocatalysis, aromatization, annulation, research progress