Chinese Journal of Organic Chemistry ›› 2020, Vol. 40 ›› Issue (7): 2071-2077.DOI: 10.6023/cjoc202003016 Previous Articles     Next Articles


刘仁志a,b, 杨民b, 邱观音生c, 张莲鹏d, 王玉超c, 罗劲a   

  1. a 江西师范大学分析测试中心 南昌 330022;
    b 赣南医学院基础医学院 江西赣州 341000;
    c 嘉兴学院生物与化学工程学院 南昌 330022;
    d 西南林业大学材料科学与工程学院 昆明 650224
  • 收稿日期:2020-03-07 修回日期:2020-04-04 发布日期:2020-04-17
  • 通讯作者: 邱观音生, 张莲鹏, 罗劲;;
  • 基金资助:

Base-Free 5-exo-dig aza-Cyclization of N-Methoxyl-2-alkynylbenzamides in Water

Liu Renzhia,b, Yang Minb, Qiu Guanyinshengc, Zhang Lianpengd, Wang Yuchaoc, Luo Jina   

  1. a Analytical and Testing Center, Jiangxi Normal University, Nanchang 330022;
    b Department of Forensic Science, Gannan Medical University, Ganzhou 341000;
    c College of Biological, Chemical Sciences and Engineering, Jiaxing University, Jiaxing 314001;
    d School of Materials Science and Engineering, Southwest Forestry University, Kunming 650224 China
  • Received:2020-03-07 Revised:2020-04-04 Published:2020-04-17
  • Supported by:
    Project supported by the National Natural Science Foundation of China (Nos. 21772067, 21502069).

A based-free 5-exo-dig aza-cyclization of N-methoxyl-2-alkynylbenzamides in water is reported for the synthesis of various N-methoxylisoindolin-1-ones. The transformation proceeds smoothly with high efficiency and good functional group tolerance. In the process, it is believed that N-methoxyl protecting group serves as "molecular base" to facilitate the formation of amide nitrogen anion. Interestingly, by increasing reaction temperature, a series of N-free-isoindolin-1-ones were also obtained.

Key words: water, N-methoxyl-2-alkynylbenzamide, 5-exo-dig aza-cyclization, isoindolin-1-one