Chinese Journal of Organic Chemistry ›› 2020, Vol. 40 ›› Issue (8): 2353-2373.DOI: 10.6023/cjoc202003045 Previous Articles     Next Articles


曾林伟, 崔孙良   

  1. 浙江大学药学院 药物发现与设计研究所 杭州 310058
  • 收稿日期:2020-03-18 修回日期:2020-04-29 发布日期:2020-05-11
  • 通讯作者: 崔孙良
  • 基金资助:

Recent Progress in the Addition Reaction of Electron-Rich Alkynes and Carboxylic Acids

Zeng Linwei, Cui Sunliang   

  1. Institute of Drug Discovery and Design, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058
  • Received:2020-03-18 Revised:2020-04-29 Published:2020-05-11
  • Supported by:
    Project supported by the National Natural Science Foundation of China (No. 21971222) and the Key R&D Plan of Zhejiang Province (No. 2019C03082).

Electron-rich alkynes, in which an electron-donating atom or group is attached to the triple bond, have been widely used as versatile building blocks in organic synthesis, due to their unique chemical reactivity. As an important part of electron-rich alkyne chemistry, the addition reaction between electron-rich alkynes and carboxylic acids received considerable attention these years, and various investigations and advances have been reported. The progress of addition reactions between electron-rich alkynes and carboxylic acids is summarized, and the future perspective is prospected.

Key words: electron-rich alkyne, carboxylic acid, addition reaction, hydro-acyloxylation