Chinese Journal of Organic Chemistry ›› 2024, Vol. 44 ›› Issue (1): 70-84.DOI: 10.6023/cjoc202306005 Previous Articles     Next Articles



赵红琼a, 于淼a, 宋冬雪a, 贾琦b, 刘颖杰a, 季宇彬a, 许颖a,*()   

  1. a 哈尔滨商业大学药学院 哈尔滨 150076
    b 黑龙江护理高等专科学校 哈尔滨 150086
  • 收稿日期:2023-06-05 修回日期:2023-08-09 发布日期:2023-09-08
  • 作者简介:
  • 基金资助:
    黑龙江省自然科学基金(LH2020H068); 及黑龙江省教育厅创新人才(UNPYSCT-2018139)

Progress on Decarboxylation and Hydroxylation of Carboxylic Acids

Hongqiong Zhaoa, Miao Yua, Dongxue Songa, Qi Jiab, Yingjie Liua, Yubin Jia, Ying Xua()   

  1. a School of Pharmacy, Harbin University of Commerce, Harbin 150076
    b Heilongjiang Nursing College, Harbin 150086
  • Received:2023-06-05 Revised:2023-08-09 Published:2023-09-08
  • Contact: *E-mail:
  • About author:
    These authors contributed equally to this work.
  • Supported by:
    Natural Science Foundation of Heilongjiang Province(LH2020H068); Innovative Talent Project of Ministry of Education, Heilongjiang Province(UNPYSCT-2018139)

Carboxylic acids are inexpensive, readily available, stable and functionally diverse molecules, and alcohols are used as important functional molecules in a variety of applications. Therefore, decarboxylative hydroxylation of carboxylic acid provides a direct and rapid route to important alcohol molecules from stabilized and easily obtainable carboxylic acid feedstocks through benign single carbon excision reductions, which is a very important and useful transformation in organic synthesis and nature. The research progress on decarboxylative hydroxylation reactions to obtain the corresponding primary, secondary and tertiary alcohols, mainly in terms of transition metal catalysis, photocatalysis, electrocatalysis and other types of catalysis, is highlighted with an emphasis on the possible mechanisms and applicable scope of these different reactions. Among them, transition metal catalysis emerged earlier and produced tertiary alcohols in higher yields, but with less universal substrates, whereas photocatalysis is a mild reaction with low environmental pollution and is suitable for the production of primary, secondary and tertiary alcohols.

Key words: carboxylic acid, decarboxylation and hydroxylation, alcohol, transition metal catalysis, photocatalysis