Chinese Journal of Organic Chemistry ›› 2023, Vol. 43 ›› Issue (4): 1416-1434.DOI: 10.6023/cjoc202208004 Previous Articles     Next Articles



潘永周a,b, 蒙秀金b, 王迎春c, 何慕雪a,*()   

  1. a 桂林医学院公共卫生学院 广西环境暴露组学与全生命周期健康重点实验室 广西桂林 541199
    b 广西师范大学化学与药学学院 省部共建药用资源化学与药物分子工程国家重点实验室 广西桂林 541004
    c 吉首大学化学化工学院 湖南吉首 416000
  • 收稿日期:2022-08-03 修回日期:2022-10-11 发布日期:2022-11-15
  • 通讯作者: 何慕雪
  • 基金资助:
    广西自然科学基金(2022GXNSFBA035489); 广西自然科学基金(2021GXNSFBA196041); 中央引导地方科技发展资金项目(桂科ZY21195014); “武陵山地区民族药解析与创制湖南省工程实验室”开放课题(hgxy2101)

Recent Progress in Electrochemical Fixation of CO2 to Construct Carboxylic Acid Derivatives

Yongzhou Pana,b, Xiujin Mengb, Yingchun Wangc, Muxue Hea()   

  1. a Guangxi Key Laboratory of Environmental Exposomics and Entire Lifecycle Health, School of Public Health, Guilin Medical University, Guilin, Guangxi 541199
    b State Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources, School of Chemistry and Pharmaceutical Sciences, Guangxi Normal University, Guilin, Guangxi 541004
    c College of Chemistry and Chemical Engineering, Jishou University, Jishou, Hunan 416000
  • Received:2022-08-03 Revised:2022-10-11 Published:2022-11-15
  • Contact: Muxue He
  • Supported by:
    Natural Science Foundation of Guangxi Province(2022GXNSFBA035489); Natural Science Foundation of Guangxi Province(2021GXNSFBA196041); Central Government Guides Local Science and Technology Development Fund Projects(guike ZY21195014); Opening Project of Hunan Engineering Laboratory for Analyse and Drugs Development of Ethnomedicine in Wuling Mountain(hgxy2101)

CO2 is an important C1 source in organic synthesis due to its abundant, non-toxic and low-cost properties. There- fore, it is of great significance to use CO2 as a C1 source to synthesize compounds with high added value. This review focuses on the recent progress in the carboxylation of organic compounds using CO2 as an electrophile under electrochemical conditions. The electrochemical carboxylation of non-activated organic halides, unsaturated alkene compounds and some special compounds are mainly introduced. And the use of sacrificial anodes and non-sacrificial anodes is classified in detail. The reaction mechanisms of these reactions are also discussed. This review provides a reference for the application of such reactions in organic synthesis in the future.

Key words: carbon dioxide, carboxylation, carboxylic acid derivatives, electrochemical synthesis