Chinese Journal of Organic Chemistry ›› 2020, Vol. 40 ›› Issue (10): 3214-3236.DOI: 10.6023/cjoc202005065 Previous Articles     Next Articles

Special Issue: 黄乃正院士七十华诞专辑


林晔, 杜大明   

  1. 北京理工大学化学与化工学院 北京 100081
  • 收稿日期:2020-05-23 修回日期:2020-06-13 发布日期:2020-06-20
  • 通讯作者: 杜大明

Recent Advances in Squaramide-Catalyzed Asymmetric Cascade Reactions for the Synthesis of Spirooxindoles

Lin Ye, Du Daming   

  1. School of Chemistry and Chemical Engineering, Beijing Institute of Technology, Beijing 100081
  • Received:2020-05-23 Revised:2020-06-13 Published:2020-06-20

Chiral spirooxindoles have captured huge attention from researchers in the area of organic chemistry and medicinal chemistry owing to their prevalence in various alkaloid natural products and pharmacologically active agents. In recent year, chiral bifunctional squaramide-catalyzed asymmetric cascade reaction of oxindoles or oxindole derivatives has become an efficient synthetic method for the construction of chiral spirooxindoes. In this review, the remarkable progress and advances in bifunctional squaramide-catalyzed asymmetric cascade reactions for the synthesis of spirooxindole derivatives from 2015 are summarized and discussed based on the different types of catalytic reactions.

Key words: spirooxindoles, asymmetric organocatalysis, squaramides, cascade reactions