Chinese Journal of Organic Chemistry ›› 2020, Vol. 40 ›› Issue (2): 284-299.DOI: 10.6023/cjoc201909028 Previous Articles     Next Articles


严丽君a, 徐菡a, 王艳a, 董建伟b, 王永超a   

  1. a 云南师范大学职业技术教育学院 昆明 650092;
    b 曲靖师范学院化学与环境科学学院 云南曲靖 655011
  • 收稿日期:2019-09-17 修回日期:2019-10-28 发布日期:2019-12-19
  • 通讯作者: 王永超, 董建伟;
  • 基金资助:

Advances in Multicomponent Asymmetric Cascade Synthesis Involving Nitroolefin Catalyzed by Diarylprolinol Derivatives

Yan Lijuna, Xu Hana, Wang Yana, Dong Jianweib, Wang Yongchaoa   

  1. a College of Vocational and Technical Education, Yunnan Normal University, Kunming 650092;
    b College of Chemistry and Environmental Science, Qujing Normal University, Qujing, Yunnan 655011
  • Received:2019-09-17 Revised:2019-10-28 Published:2019-12-19
  • Supported by:
    Project supported by the Applied Basic Research Project of Yunnan Provincial Department of Science and Technology (Nos. 2017FD073, 2018FD016, 2018FD081), the Scientific Research Foundation of Yunnan Provincial Education Department (No. 2017ZZX075) and the Yunnan Local Colleges Applied Basic Research Project (No. 2017FH001-092).

Nitroolefin is an important class of organic synthons. The synthetic method of multicomponent asymmetric cascade reactions involving nitroolefin catalyzed by diarlyprolinol derivatives is quite important for the construction of complex chiral compounds. It is widely used in organic synthesis and new drugs development. In this paper, the multi-component asymmetric cascade synthesis involving nitroalkenes catalyzed by diarlyprolinol derivatives is comprehensively summarized based on the type of target compounds. In detail, the catalyst systems, reaction mechanisms, experimental results, reaction advantages, existing problems and limitations for this synthetic method are introduced respectively. The future development for this synthetic period is further evaluated as well.

Key words: nitroolefin, diarlyprolinol derivatives, multicomponent reactions, asymmetric synthesis, cascade reactions