Efficient Synthesis of Tetrahydrofuran Spirooxindoles via One-Pot Reaction

doi:10.6023/cjoc202003029

Chinese Journal of Organic Chemistry ›› 2020, Vol. 40 ›› Issue (7): 1999-2007.DOI: 10.6023/cjoc202003029 Previous Articles Next Articles

四氢呋喃螺氧化吲哚衍生物的一锅法高效合成

郭欣, 郭亚军, 孔德志, 卢会杰, 华远照, 王敏灿

郑州大学化学学院绿色催化研究所郑州 450000

收稿日期:2020-03-11 修回日期:2020-04-20 发布日期:2020-04-30
通讯作者: 华远照, 王敏灿 E-mail:hyzhao@zzu.edu.cn;wangmincan@zzu.edu.cn
基金资助:
国家自然科学基金（No.21272216）、中国博士后科学基金（No.2017M622361）和河南省教育厅（Nos.17B150014，18B150028）资助项目.

Efficient Synthesis of Tetrahydrofuran Spirooxindoles via One-Pot Reaction

Guo Xin, Guo Yajun, Kong Dezhi, Lu Huijie, Hua Yuanzhao, Wang Mincan

Institute of Green Catalysis, College of Chemistry, Zhengzhou University, Zhengzhou 450000

Received:2020-03-11 Revised:2020-04-20 Published:2020-04-30
Supported by:
Project supported by the National Natural Science Foundation of China (No. 21871237), the China Postdoctoral Science Foundation (No:2017M622361) and the Education Department of Henan Province (Nos. 17B150014, 18B150028).

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Abstract

A one-pot reaction of Michael/hemiketalization and Fridel-Crafts reaction of α-hydroxy aryl ketones and β,γ-unsaturated α-ketoamides has been developed. The process enables efficient synthesis of tetrahydrofuran spirooxindoles using chain substrates that do not contain oxindole and tetrahydrofuran skeletons. A spiro-carbon center, an oxindole ring and a tetrahydrofuran ring, are constructed in this process.

Key words: one-pot, cascade reaction, tetrahydrofuran spirooxindoles

Cite this article

Guo Xin, Guo Yajun, Kong Dezhi, Lu Huijie, Hua Yuanzhao, Wang Mincan. Efficient Synthesis of Tetrahydrofuran Spirooxindoles via One-Pot Reaction[J]. Chinese Journal of Organic Chemistry, 2020, 40(7): 1999-2007.

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四氢呋喃螺氧化吲哚衍生物的一锅法高效合成

Efficient Synthesis of Tetrahydrofuran Spirooxindoles via One-Pot Reaction

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