Chinese Journal of Organic Chemistry ›› 2020, Vol. 40 ›› Issue (7): 1999-2007.DOI: 10.6023/cjoc202003029 Previous Articles     Next Articles

四氢呋喃螺氧化吲哚衍生物的一锅法高效合成

郭欣, 郭亚军, 孔德志, 卢会杰, 华远照, 王敏灿   

  1. 郑州大学化学学院 绿色催化研究所 郑州 450000
  • 收稿日期:2020-03-11 修回日期:2020-04-20 发布日期:2020-04-30
  • 通讯作者: 华远照, 王敏灿 E-mail:hyzhao@zzu.edu.cn;wangmincan@zzu.edu.cn
  • 基金资助:
    国家自然科学基金(No.21272216)、中国博士后科学基金(No.2017M622361)和河南省教育厅(Nos.17B150014,18B150028)资助项目.

Efficient Synthesis of Tetrahydrofuran Spirooxindoles via One-Pot Reaction

Guo Xin, Guo Yajun, Kong Dezhi, Lu Huijie, Hua Yuanzhao, Wang Mincan   

  1. Institute of Green Catalysis, College of Chemistry, Zhengzhou University, Zhengzhou 450000
  • Received:2020-03-11 Revised:2020-04-20 Published:2020-04-30
  • Supported by:
    Project supported by the National Natural Science Foundation of China (No. 21871237), the China Postdoctoral Science Foundation (No:2017M622361) and the Education Department of Henan Province (Nos. 17B150014, 18B150028).

A one-pot reaction of Michael/hemiketalization and Fridel-Crafts reaction of α-hydroxy aryl ketones and β,γ-unsaturated α-ketoamides has been developed. The process enables efficient synthesis of tetrahydrofuran spirooxindoles using chain substrates that do not contain oxindole and tetrahydrofuran skeletons. A spiro-carbon center, an oxindole ring and a tetrahydrofuran ring, are constructed in this process.

Key words: one-pot, cascade reaction, tetrahydrofuran spirooxindoles