Chinese Journal of Organic Chemistry ›› 2021, Vol. 41 ›› Issue (1): 341-347.DOI: 10.6023/cjoc202006062 Previous Articles     Next Articles


锰介导的Reformatsky反应: 高效合成多样化 β-羟基链烷酸酯

夏艳萍a, 欧阳露a, 廖建华a, 魏一飞a, 罗人仕a,*()   

  1. a 赣南医学院药学院 江西赣州 341000
  • 收稿日期:2020-06-29 修回日期:2020-07-30 发布日期:2020-08-27
  • 通讯作者: 罗人仕
  • 作者简介:
    * Corresponding author. E-mail:
  • 基金资助:
    国家自然科学基金(21962004); 国家自然科学基金(21562004); 江西省自然科学基金(20192BAB203004); 赣南医学院(QD201810); 赣南医学院(YJ202027)

Manganese-Mediated Reformatsky Reaction: Highly Divergent Synthesis ofβ-Hydroxyalkanoates

Yanping Xiaa, Lu Ouyanga, Jianhua Liaoa, Yifei Weia, Renshi Luoa,*()   

  1. a School of Pharmacy, Gannan Medical University, Ganzhou, Jiangxi 341000
  • Received:2020-06-29 Revised:2020-07-30 Published:2020-08-27
  • Contact: Renshi Luo
  • Supported by:
    the the National Natural Science Foundation of China(21962004); the the National Natural Science Foundation of China(21562004); Jiangxi provincial department of science and technology(20192BAB203004); Gannan Medical University(QD201810); Gannan Medical University(YJ202027)

A practical, flexible, and efficient manganese-mediated catalytic system of Reformatsky reaction has been described. The cheap and readily available manganese powder acts as the reaction mediator, which conducts effectively for the preparation of useful β-hydroxyalkanoate compounds with the nickel catalyst in excellent yields (up to 98%) and mild condition. In addition, the catalytic methodology can be scaled up to the gram scale.

Key words: manganese, nickel catalyst, reformatsky, aldehydes and ketones, β-hydroxyalkanoates